de-O-methyllasiodiplodin

Base Information Edit

Chemical Name:de-O-methyllasiodiplodin
CAS No.:32885-82-8
Molecular Formula:C₁₆H₂₂O₄
Molecular Weight:278.348
Hs Code.:
DSSTox Substance ID:DTXSID001312913
Nikkaji Number:J373.402A
Wikidata:Q105178420
Mol file:32885-82-8.mol

Synonyms:de-O-methyllasiodiplodin

Suppliers and Price of de-O-methyllasiodiplodin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

CSNpharm
De-O-Methyllasiodiplodin
5mg
$ 974.00

CSNpharm
De-O-Methyllasiodiplodin
1mg
$ 390.00

Total 10 raw suppliers

Chemical Property of de-O-methyllasiodiplodin Edit

Chemical Property:

Melting Point:120-125℃ (hexane )
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:278.15180918
Heavy Atom Count:20
Complexity:318

Purity/Quality:

99% ^*data from raw suppliers

De-O-Methyllasiodiplodin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CCCCCCCC2=C(C(=CC(=C2)O)O)C(=O)O1
Isomeric SMILES:C[C@H]1CCCCCCCC2=C(C(=CC(=C2)O)O)C(=O)O1

Technology Process of de-O-methyllasiodiplodin

There total 20 articles about de-O-methyllasiodiplodin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 125520-75-4
(R)-14-hydroxy-12-methoxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-benzo[c][1]oxacyclododecin-1-one

: 32885-82-8,130932-26-2
(R)-de-O-Methyllasiodiplodin

Guidance literature:: With aluminium(III) iodide; tetra-(n-butyl)ammonium iodide; In benzene; at 10 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/ejoc.201501545

Reference yield: 57.0%

: 125590-95-6
(+)-(R)-12,14-dimethoxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-benzo[c][1]oxacyclododecin-1-one

: 32885-82-8,130932-26-2
(R)-de-O-Methyllasiodiplodin

Guidance literature:: (+)-(R)-12,14-dimethoxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-benzo[c][1]oxacyclododecin-1-one; With boron tribromide; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

With water; In dichloromethane; for 0.0833333h;
DOI:10.1016/j.bmcl.2010.12.101

Reference yield:

: 539-87-7
oxocan-2-one

: 32885-82-8,130932-26-2
(R)-de-O-Methyllasiodiplodin

Guidance literature:: Multi-step reaction with 11 steps

1: conc. H₂SO₄ / 2 h / Ambient temperature

2: 80 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: NaI, NaHCO₃ / acetone / 72 h / Ambient temperature

4: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) 5 min

5: 98 percent / Na₂HPO₄, 6percent sodium amalgam / methanol / 1 h / -20 °C

6: 1.) LDA / 1.) THF, -30 deg C, 0.5 h, 2.) -78 deg C

7: DIBAL / hexane; tetrahydrofuran / 1 h / -78 °C

8: 53 percent / Raney Ni / ethanol / 0.5 h

9: 74 percent / 10 N KOH / ethane-1,2-diol / 4 h / 165 °C

10: 1.) di-(2-pyridyl) disulfide, Ph₃P, 2.) AgClO₄ / 1.) benzene, 1 h, 2.) CH₃CN, 160 deg C, 30 min

11: 17 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; 2,2'-dipyridyldisulphide; sulfuric acid; silver perchlorate; boron tribromide; nickel; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethylene glycol; acetone;
DOI:10.1016/0957-4166(90)90013-Z