N,N-dimethylpiperidine-4-carboxamide hydrochloride

Base Information

• Chemical Name: N,N-dimethylpiperidine-4-carboxamide hydrochloride
• CAS No.: 6270-42-4
• Molecular Formula: C8H16N2O.ClH
• Molecular Weight: 192.689
• Hs Code.: 2933399090
• European Community (EC) Number: 816-912-4
• DSSTox Substance ID: DTXSID60600863
• NSC Number: 35515
• Mol file: 6270-42-4.mol

Synonyms:6270-42-4;N,N-dimethylpiperidine-4-carboxamide hydrochloride;Piperidine-4-carboxylic acid dimethylamide HCl;N,N-DIMETHYLPIPERIDINE-4-CARBOXAMIDE HCL;N,N-dimethylpiperidine-4-carboxamide;hydrochloride;N,N-DIMETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE;4-Piperidinecarboxamide, N,N-dimethyl-, monohydrochloride;SCHEMBL1018967;DTXSID60600863;AQEDPORECJZBIA-UHFFFAOYSA-N;NSC35515;NSC-35515;AKOS015846352;SB41249;N,N-Dimethyl-4-piperidinecarboxamide HCl;DB-308833;CS-0141260;EN300-35726;P10493;N,N-dimethylpiperidine-4-carboxamidehydrochloride;A855919;A1-01466;F2145-0671;4-Piperidinecarboxamide,N,N-dimethyl-,hydrochloride(1:1);N,N-Dimethylpiperidine-4-carboxamide--hydrogen chloride (1/1);N,N-Dimethyl-4-piperidinecarboxamide hydrochloride

Chemical Property of N,N-dimethylpiperidine-4-carboxamide hydrochloride

Chemical Property:

• Melting Point: 145-146 °C
• Boiling Point: 304.2 °C at 760 mmHg
• Flash Point: 137.8 °C
• PSA: 32.34000
• LogP: 1.20500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 192.1029409
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethyl-4-piperidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C1CCNCC1.Cl

Technology Process of N,N-dimethylpiperidine-4-carboxamide hydrochloride

There total 2 articles about N,N-dimethylpiperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester (254905-58-3) → N,N-dimethylpiperidine-4-carboxamide hydrochloride (6270-42-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.5h;

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → N,N-dimethylpiperidine-4-carboxamide hydrochloride (6270-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; HATU / dichloromethane / 20 °C

2: hydrogenchloride / methanol / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In methanol; dichloromethane;

Reference yield: 85.0%

N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide (1189852-16-1) + N,N-dimethylpiperidine-4-carboxamide hydrochloride (6270-42-4) + trifluoroacetic acid (76-05-1) → 1-(5-(4-(2-hydroxypropan-2-yl)benzamido)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylpiperidine-4-carboxamide trifluoroacetate

Guidance literature:

N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide; N,N-dimethylpiperidine-4-carboxamide hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile; HPLC;

upstream raw materials:

4-(dimethylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Refernces

• 1、 -. "PHARMACEUTICAL COMPOUNDS". Page/Page column 51-52. . Retrieved 2008/06/13.