5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin

Base Information

• Chemical Name: 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin
• CAS No.: 157365-67-8
• Molecular Formula: C₁₄H₁₀N₄O₃S
• Molecular Weight: 314.324
• Mol file: 157365-67-8.mol

Synonyms:

Chemical Property of 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin

There total 1 articles about 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde (1195-08-0) + 3-phenyl-2-thioxoimidazolidin-4-one (2010-15-3) → 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin (157365-67-8)

Guidance literature:

With sodium acetate; In acetic acid; for 4h; Heating;

DOI:10.1007/BF00811853

Reference yield:

5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin (157365-67-8) → 5-<1-(2-deoxy-α-D-erythro-pentofuranosyl)uracil-5-ylmethylene>-3-phenyl-2-thiohydantoin

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (Me₃Si)2NH, (NH₄)2SO₄, 2.) CF₃SO₃SiMe₃ / 1.) reflux, overnight, 2.) MeCN, -50 deg C, 2 h; -10 deg C, overnight; r.t., overnight

2: 9 percent / NaOMe / methanol

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; sodium methylate; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol;

DOI:10.1007/BF00811853

Reference yield:

5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin (157365-67-8) → 5-<1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil-5-ylmethylene>-3-phenyl-2-thiohydantoin

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (Me₃Si)2NH, (NH₄)2SO₄, 2.) CF₃SO₃SiMe₃ / 1.) reflux, overnight, 2.) MeCN, -50 deg C, 2 h; -10 deg C, overnight; r.t., overnight

2: 11 percent / NaOMe / methanol

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; sodium methylate; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol;

DOI:10.1007/BF00811853

upstream raw materials:

2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

3-phenyl-2-thioxoimidazolidin-4-one

Refernces