1,3'-Dimethylguanosine

Base Information

• Chemical Name: 1,3'-Dimethylguanosine
• CAS No.: 74466-66-3
• Molecular Formula: C₁₂H₁₇N₅O₅
• Molecular Weight: 311.297
• Mol file: 74466-66-3.mol

Synonyms:

Chemical Property of 1,3'-Dimethylguanosine

Chemical Property:

• Boiling Point: 685.6±65.0 °C(Predicted)
• Density: 1.81±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,2’-O-Dimethylguanosine is a dimethyl analogue of Guanosine (G837895), a purine nucleoside and a novel influenza neuraminidase inhibitor.

Technology Process of 1,3'-Dimethylguanosine

There total 6 articles about 1,3'-Dimethylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

trimethylsulphonium hydroxide (17287-03-5) + G (118-00-3) → 1,2'-Dimethylguanosine (73667-71-7) + 1,3'-Dimethylguanosine (74466-66-3) + 1-methylguanosine (2140-65-0) + 6-O-methylguanosine (7803-88-5)

Guidance literature:

In methanol; N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;

Reference yield: 18.0%

trimethylsulphonium hydroxide (17287-03-5) + G (118-00-3) → 3’-O-methylguanosine (10300-27-3) + 2'-O-methylguanosine (2140-71-8) + 1,3'-Dimethylguanosine (74466-66-3) + 1-methylguanosine (2140-65-0)

Guidance literature:

With copper acetylacetonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;

DOI:10.1021/jo01307a026

Reference yield: 12.0%

trimethylsulphonium hydroxide (17287-03-5) + G (118-00-3) → 2'-O-methylguanosine (2140-71-8) + 1,2'-Dimethylguanosine (73667-71-7) + 1,3'-Dimethylguanosine (74466-66-3) + 1-methylguanosine (2140-65-0)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;

DOI:10.1021/jo01307a026

upstream raw materials:

trimethylsulphonium hydroxide

G

trimethylphenylammonium hydroxide

Refernces

• 1、 Yamauchi, Kiyoshi,Nakagima, Toru,Kinoshita, Masayoshi. "Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides". . p. 2787 - 2792. Retrieved 2007/10/02.