O-diacetyl methyl-(+/-)-β-conidendral

Base Information Edit

Chemical Name:O-diacetyl methyl-(+/-)-β-conidendral
CAS No.:71724-97-5
Molecular Formula:C₂₅H₂₈O₈
Molecular Weight:456.493
Hs Code.:
Mol file:71724-97-5.mol

Synonyms:

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Chemical Property of O-diacetyl methyl-(+/-)-β-conidendral Edit

Chemical Property:

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Technology Process of O-diacetyl methyl-(+/-)-β-conidendral

There total 22 articles about O-diacetyl methyl-(+/-)-β-conidendral which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 108-24-7
acetic anhydride

: 71724-99-7,71772-19-5,101312-79-2,105817-21-8,105817-25-2
methyl epi-1-(+/-)-α-conidendral

: 71724-97-5,71772-16-2,101312-81-6,105817-22-9,105817-26-3
O-diacetyl methyl epi-1-(+/-)-α-conidendral

Guidance literature:: With pyridine; for 3h; Heating;
DOI:10.1016/S0040-4020(01)87617-1

Reference yield:

: 72724-00-6
1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene

: 71724-97-5,71772-16-2,101312-81-6,105817-22-9,105817-26-3
O-diacetyl methyl epi-1-(+/-)-α-conidendral

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA, 2.) HMPT / 1.) THF, -80 deg C, 1h 30 min. 2.) THF, 12 h

2: 91 percent / HgO, BF₃*Et₂O / tetrahydrofuran / 20 h / Ambient temperature

3: 76 percent / NaBH₄ / methanol; CH₂Cl₂ / 3 h / Ambient temperature

4: 95 percent / CF₃COOH / CH₂Cl₂ / 3 h / 10 °C

5: 92 percent / DIBAL / toluene; CH₂Cl₂ / 3 h / -78 °C

6: 84 percent / CF₃COOH / CH₂Cl₂ / 2.5 h / 14 - 20 °C

7: 70 percent / H₂ / Pd/C 10percent / ethyl acetate / 2250.2 Torr / Ambient temperature

8: 75 percent / pyridine / 3 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; diisobutylaluminium hydride; trifluoroacetic acid; mercury(II) oxide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4020(01)87617-1

Reference yield:

: 72724-00-6
1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene

: 71724-97-5,71772-16-2,101312-81-6,105817-22-9,105817-26-3
O-diacetyl methyl-(+/-)-β-conidendral

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) LDA, 2.) HMPT / 1.) THF, -80 deg C, 1h 30 min. 2.) THF, 12 h

2: 91 percent / HgO, BF₃*Et₂O / tetrahydrofuran / 20 h / Ambient temperature

3: 76 percent / NaBH₄ / methanol; CH₂Cl₂ / 3 h / Ambient temperature

4: 95 percent / CF₃COOH / CH₂Cl₂ / 3 h / 10 °C

5: 86 percent / NaOMe / methanol; CH₂Cl₂ / 1 h / Heating

6: 84 percent / DIBAL / CH₂Cl₂; toluene / 3 h / -78 °C

7: 84 percent / CF₃COOH / 3 h / Ambient temperature

8: 76 percent / H₂ / Pd/C 10percent / ethyl acetate

9: 75 percent / pyridine / 0.25 h / Heating

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; diisobutylaluminium hydride; trifluoroacetic acid; mercury(II) oxide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4020(01)87617-1