BendaMustine IMpurity A

Base Information

• Chemical Name: BendaMustine IMpurity A
• CAS No.: 109882-26-0
• Molecular Formula: C16H22ClN3O3.ClH
• Molecular Weight: 376.27800
• Mol file: 109882-26-0.mol

Synonyms:4-{5-[(2-Chloro-ethyl)-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid;hydrochloride;

Chemical Property of BendaMustine IMpurity A

Chemical Property:

• PSA: 78.59000
• LogP: 2.82010

Purity/Quality:

95-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BendaMustine IMpurity A

There total 2 articles about BendaMustine IMpurity A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bendamustine hydrochloride (3543-75-7,97832-05-8) → 4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazolyl(2))butyric acid hydrochloride (109882-26-0)

Guidance literature:

bendamustine hydrochloride; With potassium carbonate; at 25 ℃; for 1h;

With hydrogenchloride; In water; acetonitrile; pH=5;

Reference yield:

bendamustine hydrochloride (3543-75-7,97832-05-8) → 4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid (109882-29-3) + 4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazolyl(2))butyric acid hydrochloride (109882-26-0)

Guidance literature:

With water; at 95 ℃; for 1h;

upstream raw materials:

bendamustine hydrochloride

Refernces

• 1、 Werner,Letsch,Ihn. "Hydrolysis products of the cancerostatic drug Cytostasan (Bendamustin)". . p. 272 - 273. Retrieved 2007/10/02.