2-cyanoetoricoxib

Base Information

• Chemical Name: 2-cyanoetoricoxib
• CAS No.: 1616667-35-6
• Molecular Formula: C₁₉H₁₄ClN₃O₂S
• Molecular Weight: 383.858
• Mol file: 1616667-35-6.mol

Synonyms:

Chemical Property of 2-cyanoetoricoxib

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyanoetoricoxib

There total 2 articles about 2-cyanoetoricoxib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

etoricoxib (202409-33-4) → 2-cyanoetoricoxib (1616667-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: silver(II) fluoride / acetonitrile / 2 h / 50 °C / Inert atmosphere; Glovebox; Sealed tube

2: N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere; Glovebox; Sealed tube

With silver(II) fluoride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja5049303

Reference yield:

potassium cyanide + C18H14ClFN2O2S (1616667-32-3) → 2-cyanoetoricoxib (1616667-35-6)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/ja5049303

upstream raw materials:

C₁₈H₁₄ClFN₂O₂S

etoricoxib

Refernces

• 1、 Fier, Patrick S.,Hartwig, John F.. "Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution". supporting information. p. 10139 - 10147. Retrieved 2014/08/05.