17(S)-HDoHE

Base Information

• Chemical Name: 17(S)-HDoHE
• CAS No.: 92693-03-3
• Molecular Formula: C₂₂H₃₂O₃
• Molecular Weight: 344.494
• Mol file: 92693-03-3.mol

Synonyms:

Chemical Property of 17(S)-HDoHE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

17(S)-HDHA ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17(S)-HDoHE

There total 2 articles about 17(S)-HDoHE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

docosahexaenoic acid (6217-54-5) → (17S)-HDHA (92693-03-3)

Guidance literature:

docosahexaenoic acid; With lipoxidase from soybean; oxygen; at 0 ℃; pH=9; Enzymatic reaction;

With triphenylphosphine; In hexane; ethyl acetate; at 0 - 4 ℃;

DOI:10.1016/j.tetlet.2018.02.029

Reference yield:

17(S)-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (123673-33-6) → (17S)-HDHA (92693-03-3)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

(17S)-HDHA (92693-03-3) → Benzoic acid (2E,4Z,7Z,10Z,13Z)-(S)-16-methoxycarbonyl-1-((Z)-pent-2-enyl)-hexadeca-2,4,7,10,13-pentaenyl ester

Guidance literature:

Multi-step reaction with 2 steps

2: triethylamine, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; triethylamine; In dichloromethane;

DOI:10.1246/bcsj.69.1663

upstream raw materials:

docosahexaenoic acid

17(S)-hydroperoxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid

Downstream raw materials:

17-oxo-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid

(±)-(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoic acid

Refernces

• 1、 -. "RESOLVINS: BIOTEMPLATES FOR NOVEL THERAPEUTIC INTERVENTIONS". Page 101; 105. . Retrieved 2008/06/13.