4-methyl-2-(1-methylethyl)-3-pyridinamine

Base Information

• Chemical Name: 4-methyl-2-(1-methylethyl)-3-pyridinamine
• CAS No.: 1698293-93-4
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.224
• Mol file: 1698293-93-4.mol

Synonyms:

Chemical Property of 4-methyl-2-(1-methylethyl)-3-pyridinamine

Chemical Property:

• Boiling Point: 267.7±35.0 °C(Predicted)
• Density: 0.992±0.06 g/cm3(Predicted)

Purity/Quality:

98%, ^*data from raw suppliers

2-Isopropyl-4-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Used as reagent to prepare KRAS G12C inhibitors which are useful for treatment pancreatic, colorectal and lung cancer.

Technology Process of 4-methyl-2-(1-methylethyl)-3-pyridinamine

There total 20 articles about 4-methyl-2-(1-methylethyl)-3-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-3-nitro-2-isopropenylpyridine (1269438-44-9) → 4-methyl-2-(1-methylethyl)-3-pyridinamine (1698293-93-4)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; at 20 ℃; for 4h;

Reference yield: 98.0%

3-amino-2-bromo-4-methylpyridine (126325-50-6) + isopropyl zinc bromide (77047-87-1) → 4-methyl-2-(1-methylethyl)-3-pyridinamine (1698293-93-4)

Guidance literature:

3-amino-2-bromo-4-methylpyridine; isopropyl zinc bromide; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; at 60 ℃; for 17h; Inert atmosphere;

With sodium hydroxide; In water;

DOI:10.1021/acs.jmedchem.9b01180

Reference yield: 89.0%

2-isopropyl-4-methylnicotinamide → 4-methyl-2-(1-methylethyl)-3-pyridinamine (1698293-93-4)

Guidance literature:

2-isopropyl-4-methylnicotinamide; With sodium hypochlorite; sodium hydroxide; In water; for 0.166667h;

2-isopropyl-4-methylnicotinamide; In water; at 5 ℃; for 4h;

upstream raw materials:

3-amino-2-bromo-4-methylpyridine

isopropyl zinc bromide

isopropylmagnesium chloride

2-chloro-3-nitro-4-methylpyridine

Downstream raw materials:

7-chloro-6-fluoro- 1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one

Refernces

• 1、 -. "OGA INHIBITOR COMPOUNDS". Page/Page column 40. . Retrieved 2021/06/26.
• 2、 -. "KRAS MUTANT PROTEIN INHIBITOR". Page/Page column 51-52. . Retrieved 2021/05/15.