PROPARGYL P-TOLUENESULFONATE

Base Information

• Chemical Name: PROPARGYL P-TOLUENESULFONATE
• CAS No.: 16192-07-7
• Molecular Formula: C10H10O2S
• Molecular Weight: 194.254
• Hs Code.: 2904100000
• Mol file: 16192-07-7.mol

Synonyms:Benzene,1-methyl-4-(2-propynylsulfonyl)- (9CI);Sulfone, 2-propynyl p-tolyl (8CI);1-Methyl-4-(2-propynylsulfonyl)benzene;3-(4-Tolylsulfonyl)propyne;Propargylp-toluenesulfonate;p-Tolyl prop-2-ynyl sulfone;

Chemical Property of PROPARGYL P-TOLUENESULFONATE

Chemical Property:

• Appearance/Colour: Clear, colorless to yellow liquid.
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 343.983 °C at 760 mmHg
• Flash Point: 197.534 °C
• PSA: 42.52000
• Density: 1.183 g/cm³
• LogP: 2.48270
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, Dichloromethane, DMSO, Ethyl Acetate

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): R22:; R36/37/38:
• Hazard Codes: Xn:Harmful
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Propargyl. A possible genotoxic compound that can affect the bacterial and mammalian cell systems.

Technology Process of PROPARGYL P-TOLUENESULFONATE

There total 17 articles about PROPARGYL P-TOLUENESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methylphenyl prop-2'-ynyl sulfide (33597-89-6) → 4-tosylacetonitrile (16192-07-7)

Guidance literature:

With dihydrogen peroxide; In diethyl ether; acetic acid; for 3h; Heating;

DOI:10.1002/oms.1210200404

Reference yield: 73.0%

p-toluenesulfonyl chloride (98-59-9) → 4-tosylacetonitrile (16192-07-7)

Guidance literature:

With pyridine; In chloroform; at 25 ℃; for 2h; Irradiation;

Reference yield: 68.0%

p-toluenesulfonyl chloride (98-59-9) → 4-tosylacetonitrile (16192-07-7)

Guidance literature:

With pyridine; In chloroform; at 25 ℃; for 2h; Irradiation;

upstream raw materials:

4-methylphenyl prop-2'-ynyl sulfide

p-toluene sulfinic acid

propargyl bromide

p-toluenesulfonyl chloride

Downstream raw materials:

p-tolylsulfonylallene

4-toluenesulfonylacetone

(E)-1-phenyl-2-tosyl-1-buten-3-yne

(3S,3aR,6aS,SS)-3-ethoxy-6a[(4-methylphenyl)sulfinyl]-5-[(4-methylphenyl)sulfonyl]-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]furan-1-one

Refernces

• 1、 Fu, Ying,Xu, Qin-Shan,Li, Quan-Zhou,Du, Zhengyin,Wang, Ke-Hu,Huang, Danfeng,Hu, Yulai. "Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides". . p. 2841 - 2845. Retrieved 2017/04/03.
• 2、 Nunez Jr., Alberto,Rosario Martin,Fraile, Alberto,Garcia Ruano, Jose L.. "Abnormal behaviour of allenylsulfones under Lu's reaction conditions: Synthesis of enantiopure polyfunctionalised cyclopentenes". scheme or table. p. 5443 - 5453. Retrieved 2010/10/03.