6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione
• CAS No.: 1166378-30-8
• Molecular Formula: C₈H₄BrClN₂O₂
• Molecular Weight: 275.489
• Mol file: 1166378-30-8.mol

Synonyms:

Chemical Property of 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-7-chloroquinazoline-2,4-diol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione

There total 2 articles about 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-5-bromo-4-chlorobenzene carboxylic acid (50419-88-0) + urea (57-13-6) → 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione (1166378-30-8)

Guidance literature:

2-amino-5-bromo-4-chlorobenzene carboxylic acid; urea; at 160 ℃; for 6h;

With sodium hydroxide; In water; Heating;

DOI:10.1021/jm901379s

Reference yield: 92.0%

→ 6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione (1166378-30-8)

Guidance literature:

Reference yield: 40.0%

6-bromo-7-chloroquinazoline-2,4(1H,3H)-dione (1166378-30-8) → 2,4,7-trichloro-6-bromoquinazoline (1166378-32-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; Reflux;

DOI:10.1021/jm901379s

upstream raw materials:

2-amino-5-bromo-4-chlorobenzene carboxylic acid

urea

Downstream raw materials:

2,4,7-trichloro-6-bromoquinazoline

Refernces

• 1、 -. "Quinazolines and related heterocyclic compounds and their therapeutic use". Page/Page column 19. . Retrieved 2009/07/18.