Ranitidine hydrochloride

Base Information

• Chemical Name: Ranitidine hydrochloride
• CAS No.: 71130-06-8
• Molecular Formula: C₁₃H₂₂N₄O₃S*ClH
• Molecular Weight: 350.87
• Hs Code.: 2933990090
• European Community (EC) Number: 266-332-5,275-207-4
• NSC Number: 757851
• DSSTox Substance ID: DTXSID101112063
• Nikkaji Number: J1.096.093B,J19.096I
• Wikipedia: Ranitidine
• Wikidata: Q21971328
• NCI Thesaurus Code: C29412,C66506
• RXCUI: 9143,203136
• Pharos Ligand ID: 4J58WU3QL6MK
• Metabolomics Workbench ID: 37937
• ChEMBL ID: CHEMBL512
• Mol file: 71130-06-8.mol

Synonyms:AH 19065;AH-19065;AH19065;Biotidin;Hydrochloride, Ranitidine;N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine;Ranisen;Ranitidin;Ranitidine;Ranitidine Hydrochloride;Sostril;Zantac;Zantic

Chemical Property of Ranitidine hydrochloride

Chemical Property:

• Appearance/Colour: tan solid
• Boiling Point: 437.1 °C at 760 mmHg
• Flash Point: 218.2 °C
• PSA: 111.56000
• LogP: 3.56600
• Solubility.: H2O: 1.8 mg/mL
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 314.14126175
• Heavy Atom Count: 21
• Complexity: 347

Purity/Quality:

99%MIN ^*data from raw suppliers

RanitidineHCl ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Drug Classes: Antiulcer Agents
• Canonical SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
• Isomeric SMILES: CN/C(=C\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C
• Recent ClinicalTrials: Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel
• Recent EU Clinical Trials: The added value of the H2-antagonist ranitidine in premedication regimens during paclitaxel treatment
• Recent NIPH Clinical Trials: Effects of Daijokito on the pharmacokinetics of H2 blocker ranitidine.
• Uses: A histamine H2-receptor antagonist

Technology Process of Ranitidine hydrochloride

There total 4 articles about Ranitidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.84%

Ranitidine (66357-35-5,70956-04-6) → ranitidine hydrochloride (66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 ℃; pH=4.5 - 6.5; Temperature; pH-value;

Reference yield: 91.7%

ranitidine (66357-35-5,70956-04-6) → ranitidine hydrochloride (66357-35-5,66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 25 ℃; for 0.75h;

Reference yield:

2-methylamino-2-methylthio-1-nitroethene (102721-76-6,61832-41-5) + 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine (66356-53-4) → ranitidine hydrochloride (66357-59-3,71130-06-8,358638-36-5)

Guidance literature:

2-methylamino-2-methylthio-1-nitroethene; 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine; In water; at 38 ℃; for 7h; under 75.0075 - 225.023 Torr;

With hydrogenchloride; In ethanol; water; at 0 - 3 ℃; under 225.023 - 375.038 Torr; pH=6.3; Temperature;

upstream raw materials:

Ranitidine

2-methylamino-2-methylthio-1-nitroethene

5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine

ranitidine

Downstream raw materials:

C₁₃H₂₂N₄O₄S

Ranitidine S-oxide

N-methylnitroacetamide

5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine

Refernces

• 1、 -. "Preparation method of high-transmittance ranitidine hydrochloride". Paragraph 0014; 0015. . Retrieved 2017/12/27.
• 2、 -. "ANHYDROUS TABLET OF RANITIDINE HYDROCHLORIDE WITH DOUBLE-LAYER COATING AND ITS COMPOSITION". Page/Page column 7. . Retrieved 2008/06/13.