SRT1720

Base Information

• Chemical Name: SRT1720
• CAS No.: 1001645-58-4
• Molecular Formula: C25H23N7OS.HCl
• Molecular Weight: 506.02
• Hs Code.: 2934100090
• Mol file: 1001645-58-4.mol

Synonyms:SRT-1720;

Chemical Property of SRT1720

Chemical Property:

• PSA: 115.69000
• Density: 1.58
• LogP: 4.80520
• Storage Temp.: = -70C
• Solubility.: Soluble in DMSO (>25 mg/ml)

Purity/Quality:

98%,99%, ^*data from raw suppliers

SRT1720Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 (1001645-58-4) is a SIRT1 activator (EC1.5 = 0.16 μM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/ob mice and Zucker fa/fa rats.? SRT1720 enhanced endurance running and protected against diet-induced obesity and insulin resistance via enhancement of oxidative metabolism in skeletal muscle, liver, and brown adipose tissue.2 It induced mitochondrial biogenesis in oxidant-induced renal proximal tube cell injury.3 SRT1720 repressed circadian clock gene expression and decreased H3 K9/K14 acetylation in a time-specific manner.4 It attenuated angiotensin II-induced atherosclerosis by inhibiting the vascular inflammatory response.5
• Uses: SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.