Fluoxetine hydrochloride

Base Information

• Chemical Name: Fluoxetine hydrochloride
• CAS No.: 59333-67-4
• Molecular Formula: C₁₇H₁₈F₃NO
• Molecular Weight: 309.331
• Hs Code.: 29221990
• Mol file: 59333-67-4.mol

Synonyms:Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride;N-Methyl-gama-[4-(trifluoromethyl);Motivone;CCRIS 7093;Cramin;Depreks;Digassim;Felicium;Equilibrane;Fluoxetine HCl;

Chemical Property of Fluoxetine hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 1.47E-13mmHg at 25°C
• Melting Point: 158-159 °C
• Refractive Index: 1.63
• Boiling Point: 395.1 °C at 760 mmHg
• Flash Point: 192.8 °C
• PSA: 21.26000
• Density: 1.254g/cm3
• LogP: 5.62790
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: 4 mg/mL

Purity/Quality:

99.9% ^*data from raw suppliers

TSCOT ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,T,F
• Statements: 22-38-41-39/23/24/25-23/24/25-11
• Safety Statements: 26-36/37/39-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A selectiive derotonin reuptake inhibitor. Used as an antidepressant Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI),it is used as an antidepressant. Antidepressant;5-HT uptake inhibitor

Technology Process of Fluoxetine hydrochloride

There total 47 articles about Fluoxetine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2,2-trifluoro-N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide → FLUOXETINE (54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1039/c9ob02635e

Reference yield: 87.0%

3-methylamino-1-phenylpropan-1-ol (42142-52-9) + 4-chlorobenzotrifluoride (98-56-6) → FLUOXETINE (54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4)

Guidance literature:

3-methylamino-1-phenylpropan-1-ol; With sodium hydride; In dimethyl sulfoxide; at 60 ℃; for 1h; Inert atmosphere;

4-chlorobenzotrifluoride; In dimethyl sulfoxide; at 100 ℃; for 10h; Inert atmosphere;

With water; In diethyl ether; dimethyl sulfoxide;

DOI:10.1080/00397910903422518

Reference yield: 86.0%

3-methylamino-1-phenylpropan-1-ol (42142-52-9) + 4-hydroxybenzotrifluoride (402-45-9) → FLUOXETINE (54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4)

Guidance literature:

With tributylphosphine; di-isopropyl azodicarboxylate; In dichloromethane; N,N-dimethyl acetamide; at 70 ℃; for 0.0833333h;

DOI:10.1039/c0ob00906g

upstream raw materials:

N-benzyl-N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropyl-amine

3-(benzyl-methyl-amino)-1-phenylpropan-1-one

acetophenone

3-(N-benzyl-N-methylamino)-1-phenyl-propan-1-ol

Downstream raw materials:

N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)formamide

methyl-oxiranylmethyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]amine

C₁₈H₁₇F₃NOS₂^(1-)*Na⁽¹⁺⁾

tert-butyl 3-((N-(3-(4-trifluoromethyl)phenoxy)-3-phenylpropyl)-N-methylcarbamoyl)propylcarbamate

Refernces

• 1、 Bojarski, Andrzej J.,Bugno, Ryszard,Duszyńska, Beata,Hogendorf, Adam S.,Hogendorf, Agata,Kurczab, Rafa?,Lenda, Tomasz,Pietru?, Wojciech,Sata?a, Grzegorz,Staroń, Jakub,Wantuch, Anna,Warszycki, Dawid. "Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine". . . Retrieved 2021/06/02.
• 2、 -. "Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients". . . Retrieved 2020/12/14.