2-(2,4-Dichloro-5-fluorobenzoyl)-3-(4'-fluoro-phenylamino)-acrylic methylester

Base Information

• Chemical Name: 2-(2,4-Dichloro-5-fluorobenzoyl)-3-(4'-fluoro-phenylamino)-acrylic methylester
• CAS No.: 176637-98-2
• Molecular Formula: C17H11Cl2F2NO3
• Molecular Weight: 386.1769
• Hs Code.: 2922499990
• Mol file: 176637-98-2.mol

Synonyms:methyl (2E)-2-[(2,4-dichloro-5-fluorophenyl)carbonyl]-3-[(4-fluorophenyl)amino]prop-2-enoate

Chemical Property of 2-(2,4-Dichloro-5-fluorobenzoyl)-3-(4'-fluoro-phenylamino)-acrylic methylester

Chemical Property:

• Boiling Point: 501.2oC at 760 mmHg
• Flash Point: 256.9oC
• PSA: 55.40000
• Density: 1.465g/cm3
• LogP: 4.69630
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-((4-fluorophenyl)amino)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4-Dichloro-5-fluorobenzoyl)-3-(4'-fluoro-phenylamino)-acrylic methylester

There total 2 articles about 2-(2,4-Dichloro-5-fluorobenzoyl)-3-(4'-fluoro-phenylamino)-acrylic methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H12Cl2FNO3 + 4-fluoroaniline (371-40-4) → (Z)-methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-((4-fluorophenyl)amino)acrylate (176637-98-2)

Guidance literature:

In ethanol; at 45 ℃; for 6h;

DOI:10.1248/cpb.c17-00035

Reference yield:

N-(4-fluorophenyl)-forminino ethyl ether + methyl 2,4-dichloro-5-fluoro-benzoylacetate (103319-17-1) → methyl 3-[N-(4-fluorophenylamino)]-2-(2,4-dichloro-5-fluorobenzoyl)-acrylate (176637-98-2)

Guidance literature:

In ethanol;

upstream raw materials:

methyl 2,4-dichloro-5-fluoro-benzoylacetate

4-fluoroaniline

Refernces

• 1、 -. "Process for the preparation of N-arylaminoacrylic acid derivatives and the use of N-arylaminoacrylic acid derivatives thus prepared for the preparation of 4-quinolone-3-carboxylic acid derivatives". . . Retrieved 2008/06/13.