Cephalocyclidin A

Base Information

• Chemical Name: Cephalocyclidin A
• CAS No.: 421583-14-4
• Molecular Formula: C17H19NO5
• Molecular Weight: 317.3
• Mol file: 421583-14-4.mol

Synonyms:Cephalocyclidin A;CephalocyclidineA;8H-11,5,10a-[1]Propanyl[3]ylidene-6H-1,3-dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepine-5,13,14(11H)-triol, 9,10-dihydro-, (5S,10aR,11S,13S,14R,15R)- (9CI)

Chemical Property of Cephalocyclidin A

Chemical Property:

• Boiling Point: 545.75 °C at 760 mmHg
• Flash Point: 283.86 °C
• PSA: 82.39000
• Density: 1.675 g/cm³
• LogP: -0.16220

Purity/Quality:

98%min ^*data from raw suppliers

CephalocyclidinA 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cephalocyclidin A

There total 4 articles about Cephalocyclidin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C17H17NO5 → cephalocyclidin A (421583-14-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.202101766

Reference yield:

C19H19NO7 → cephalocyclidin A (421583-14-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: platinum(IV) oxide; hydrogen / ethanol / 16.5 h / 20 °C

1.2: 5 h / Reflux

2.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

3.3: 0.5 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With methanol; platinum(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/anie.202101766

Reference yield:

C18H17NO6 → cephalocyclidin A (421583-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

2.3: 0.5 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.202101766

Refernces