2-Amino-3-bromophenol

Base Information

• Chemical Name: 2-Amino-3-bromophenol
• CAS No.: 116435-77-9
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 29222900
• Mol file: 116435-77-9.mol

Synonyms:2-Bromo-6-hydroxyaniline;

Chemical Property of 2-Amino-3-bromophenol

Chemical Property:

• Vapor Pressure: 0.00534mmHg at 25°C
• Melting Point: 138℃
• Refractive Index: 1.677
• Boiling Point: 266.2 °C at 760 mmHg
• PKA: 8.79±0.10(Predicted)
• Flash Point: 114.8 °C
• PSA: 46.25000
• Density: 1.768 g/cm³
• LogP: 2.31810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-bromophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-3-bromophenol is a useful reagent for organic synthesis and other chemical processes.

Technology Process of 2-Amino-3-bromophenol

There total 3 articles about 2-Amino-3-bromophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-6-methoxyphenylamine (5473-01-8) → 2-amino-3-bromophenol (116435-77-9)

Guidance literature:

With boron tribromide; In methanol; dichloromethane;

Reference yield: 90.0%

N-(2-bromo-6-hydroxyphenyl)-2,6-difluorobenzamide (1431458-17-1) → 2-amino-3-bromophenol (116435-77-9)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 4h; Sealed tube;

DOI:10.1021/ol400437a

Reference yield:

3-bromo-2-nitro-phenol (76361-99-4) → 2-amino-3-bromophenol (116435-77-9)

Guidance literature:

With sodium hydroxide; sodium dithionite;

DOI:10.1039/jr9280002703

upstream raw materials:

3-bromo-2-nitro-phenol

2-bromo-6-methoxyphenylamine

N-(2-bromo-6-hydroxyphenyl)-2,6-difluorobenzamide

Downstream raw materials:

4-bromobenzo[d]-oxazole

ethyl 4-bromobenzo[d]oxazole-2-carboxylate

4-bromobenzo[d]oxazol-2-amine

4-phenyl-1,3-benzoxazol-2(3H)-one

Refernces

• 1、 -. "Biarylalkanoic acids as cell adhesion inhibitors". . . Retrieved 2008/06/13.