2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE

Base Information

• Chemical Name: 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE
• CAS No.: 1073354-14-9
• Molecular Formula: C12H16BNO3
• Molecular Weight: 233.075
• Hs Code.: 2933399090
• Mol file: 1073354-14-9.mol

Synonyms:2-Formylpyridine-5-boronic acid pinacolate

Chemical Property of 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE

Chemical Property:

• Boiling Point: 345.5±27.0 °C(Predicted)
• PKA: 3.71±0.12(Predicted)
• PSA: 48.42000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 1.19330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Formylpyridine-5-boronicAcidPinacolate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE

There total 1 articles about 2-FORMYLPYRIDINE-5-BORONIC ACID PINACOLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-pyridine-2-carbaldehyde (31181-90-5) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)picolinaldehyde (1073354-14-9)

Guidance literature:

5-bromo-pyridine-2-carbaldehyde; bis(pinacol)diborane; With potassium acetate; In tetrahydrofuran; at 20 ℃; for 0.5h;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; at 20 - 75 ℃; for 5h;

Reference yield: 91.0%

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)picolinaldehyde (1073354-14-9) → potassium (6-formylpyridin-3-yl)trifluoroborate (1245906-61-9)

Guidance literature:

With potassium hydrogenfluoride; In methanol; water; at 20 ℃; for 1h; Inert atmosphere; Saturated solution;

DOI:10.1021/ol301956p

Reference yield: 68.0%

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)picolinaldehyde (1073354-14-9) + N,N′-bis(4-bromo-2,6-diisopropylphenyl)perylene-3,4:9,10-tetracarboxylic bisimide (1308878-46-7) → C60H48N4O6

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere; Darkness;

DOI:10.1002/chem.201405866

upstream raw materials:

5-bromo-pyridine-2-carbaldehyde

bis(pinacol)diborane

Downstream raw materials:

potassium (6-formylpyridin-3-yl)trifluoroborate

N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-formylpyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-(((2-hydroxyethyl)(methyl)amino)methyl)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

Refernces