5-Bromo-1,3-dichloro-2-fluorobenzene

Base Information

• Chemical Name: 5-Bromo-1,3-dichloro-2-fluorobenzene
• CAS No.: 17318-08-0
• Molecular Formula: C6H2BrCl2F
• Molecular Weight: 243.89
• Hs Code.: 2903999090
• Mol file: 17318-08-0.mol

Synonyms:5-Bromo-1,3-dichloro-2-fluorobenzene;Benzene, 5-bromo-1,3-dichloro-2-fluoro-;LogP

Chemical Property of 5-Bromo-1,3-dichloro-2-fluorobenzene

Chemical Property:

• Vapor Pressure: 0.0815mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 234.265 °C at 760 mmHg
• Flash Point: 95.48 °C
• PSA: 0.00000
• Density: 1.824 g/cm³
• LogP: 3.89500
• Storage Temp.: Room temperature.

Purity/Quality:

99.9% ^*data from raw suppliers

5-Bromo-1,3-dichloro-2-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1,3-dichloro-2-fluorobenzene

There total 7 articles about 5-Bromo-1,3-dichloro-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

2,4-dichloro-3-fluoro-6-bromoaniline sulfate → 5-bromo-1,3-dichloro-2-fluorobenzene (17318-08-0)

Guidance literature:

With copper(II) oxide; sodium nitrite; In isopropyl alcohol; at -10 - 0 ℃; for 4h; Reagent/catalyst;

Reference yield: 83.1%

5-bromo-3-chloro-2-fluoroaniline (1517200-74-6) → 5-bromo-1,3-dichloro-2-fluorobenzene (17318-08-0)

Guidance literature:

5-bromo-3-chloro-2-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 10 ℃;

With hydrogenchloride; copper(l) chloride; In water; at 50 ℃; for 5h;

Reference yield:

1-bromo-3-chloro-4-fluorobenzene (60811-21-4) → 5-bromo-1,3-dichloro-2-fluorobenzene (17318-08-0)

Guidance literature:

1-bromo-3-chloro-4-fluorobenzene; With diisopropylaminomagnesium chloride lithium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃; for 0.25h;

With 1,1,1,3,3,3-hexachloro-propan-2-one; In tetrahydrofuran; at 0 ℃; for 0.25h; Temperature; Reagent/catalyst;

upstream raw materials:

1-bromo-3-chloro-4-fluorobenzene

2,4-dichloro-3-fluoroaniline

1,3-dichloro-2-fluoro-4-nitrobenzene

1,3-dichloro-2-fluorobenzene

Downstream raw materials:

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

(3,5-dichloro-4-fluorophenyl)boronic acid

1,3-dichloro-2-fluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

4-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

Refernces

• 1、 -. "Preparation method of 3,5-dichloro-4-fluorobromobenzene compound". Paragraph 0014; 0032; 0035-0036; 0039-0040; 0043-0044; 0047. . Retrieved 2020/12/15.
• 2、 -. "PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES". Page/Page column 7; 8. . Retrieved 2016/12/26.