9-MethoxyMethyl Guanine

Base Information

• Chemical Name: 9-MethoxyMethyl Guanine
• CAS No.: 1202645-50-8
• Molecular Formula: C₇H₉N₅O₂
• Molecular Weight: 195.181
• Hs Code.: 2933599550
• Mol file: 1202645-50-8.mol

Synonyms:

Chemical Property of 9-MethoxyMethyl Guanine

Chemical Property:

• Melting Point: >270°C (dec.)
• Boiling Point: 491.5±51.0 °C(Predicted)
• PKA: 3.21±0.20(Predicted)
• Density: 1.72±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

9-Methoxymethyl Guanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 9-MethoxyMethyl Guanine is a derivative of guanine which is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. It is used as an analyte in RP-LC for diastereometric drugs.

Technology Process of 9-MethoxyMethyl Guanine

There total 2 articles about 9-MethoxyMethyl Guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C14H15N5O2 (1429306-16-0) → methoxymethylguanine (1202645-50-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 3000.3 Torr; Autoclave;

DOI:10.1080/00397911.2011.651249

Reference yield:

2-Amino-6-benzyloxypurine (19916-73-5) → methoxymethylguanine (1202645-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 20 °C / 3000.3 Torr / Autoclave

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397911.2011.651249

upstream raw materials:

C₁₄H₁₅N₅O₂

2-Amino-6-benzyloxypurine

Refernces