(2-Bromo-6-nitro-phenyl)-acetic acid

Base Information

• Chemical Name: (2-Bromo-6-nitro-phenyl)-acetic acid
• CAS No.: 37777-74-5
• Molecular Formula: C8H6BrNO4
• Molecular Weight: 260.044
• Hs Code.: 2916399090
• Mol file: 37777-74-5.mol

Synonyms:6-Bromo-2-nitrophenylacetic acid;

Chemical Property of (2-Bromo-6-nitro-phenyl)-acetic acid

Chemical Property:

• Boiling Point: 386.263 °C at 760 mmHg
• Flash Point: 187.406 °C
• PSA: 83.12000
• Density: 1.795 g/cm³
• LogP: 2.50760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-BroMo-6-nitrophenyl)aceticAcid 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Bromo-6-nitro-phenyl)-acetic acid

There total 5 articles about (2-Bromo-6-nitro-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

6-bromo-2-nitrophenylpyruvic acid (98592-11-1) → 2-(2-bromo-6-nitrophenyl)acetic acid (37777-74-5)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; at 5 ℃; for 1h;

DOI:10.1248/cpb.33.1414

Reference yield:

(2-Bromo-6-nitro-phenyl)-acetaldehyde (85355-50-6) → 2-(2-bromo-6-nitrophenyl)acetic acid (37777-74-5)

Guidance literature:

With sodium chlorite; disodium hydrogenphosphate; aminosulfonic acid; In water; acetone; at 0 - 10 ℃; for 1h;

Reference yield:

2-bromo-6-nitrotoluene (55289-35-5) → 2-(2-bromo-6-nitrophenyl)acetic acid (37777-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium ethoxide / 1.) overnight, room temp.; reflux, 10 min; 2.) H₂O, reflux, 2 h

2: 86.4 percent / H₂O₂ (30percent), NaOH / H₂O / 1 h / 5 °C

With sodium hydroxide; dihydrogen peroxide; sodium ethanolate; In water;

DOI:10.1248/cpb.33.1414

upstream raw materials:

6-bromo-2-nitrophenylpyruvic acid

2-bromo-6-nitrotoluene

3-nitro-o-tolylamine

(2-Bromo-6-nitro-phenyl)-acetaldehyde

Downstream raw materials:

4-bromoindolin-2-one

Refernces

• 1、 Kosuge,Ishida,Inaba,Nukaya. "Synthesis and some reactions of 6-bromooxindole". . p. 1414 - 1418. Retrieved 2007/10/02.