GSK1904529A

Base Information

• Chemical Name: GSK1904529A
• CAS No.: 1089283-49-7
• Molecular Formula: C44H47F2N9O5S
• Molecular Weight: 851.977
• Mol file: 1089283-49-7.mol

Synonyms:N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide;

Chemical Property of GSK1904529A

Chemical Property:

• PKA: 11.12±0.70(Predicted)
• PSA: 158.40000
• Density: 1.397 g/cm³
• LogP: 8.33660
• Solubility.: ≥42.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Purity/Quality:

98%,99%, ^*data from raw suppliers

GSK 1904529A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A selective inhibitor of IGF-1R and IR with IC50s of 27 nM and 25 nM, respectively. GSK 1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.

Technology Process of GSK1904529A

There total 1 articles about GSK1904529A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-ethyl-2-(methyloxy)-4-{4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl}aniline (1089282-91-6) + 5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide (1089278-50-1) → GSK1904529A (1089283-49-7)

Guidance literature:

With hydrogenchloride; In 2,2,2-trifluoroethanol; at 80 - 100 ℃; sealed vessel;

DOI:10.1016/j.bmcl.2008.11.058

upstream raw materials:

5-ethyl-2-(methyloxy)-4-{4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl}aniline

5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide

Refernces