(2-Methylpyridin-4-yl)methanol

Base Information

• Chemical Name: (2-Methylpyridin-4-yl)methanol
• CAS No.: 105250-16-6
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• European Community (EC) Number: 640-594-4
• DSSTox Substance ID: DTXSID20433073
• Nikkaji Number: J1.726.869D
• Wikidata: Q82247199
• Mol file: 105250-16-6.mol

Synonyms:(2-methylpyridin-4-yl)methanol;105250-16-6;2-Methyl-4-hydroxymethylpyridine;(2-methyl-pyridin-4-yl)-methanol;4-Pyridinemethanol, 2-methyl-;(2-methyl-4-pyridinyl)methanol;2-methylpyridine-4-methanol;(2-Methyl-4-pyridyl)methanol;4-(Hydroxymethyl)-2-methylpyridine;MFCD08062415;2-METHYL-4-(HYDROXYMETHYL)PYRIDINE;SCHEMBL203588;(2-methylpyridin-4-yl)-methanol;4-Hydroxymethyl-2-Methylpyridine;DTXSID20433073;4-hydroxymethyl-2-methyl-pyridine;WCHFSXVRRCEWJL-UHFFFAOYSA-N;AMY17223;BBL101703;STL555499;AKOS006285222;CS-W011186;EG-0720;SB15807;FT-0648330;EN300-267876;A801175;W-204553;1,2,3,4-Tetrahydronaphthalene-1-carbothioicacidhydrazide;Z1198175905

Chemical Property of (2-Methylpyridin-4-yl)methanol

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 239.36 °C at 760 mmHg
• PKA: 13.46±0.10(Predicted)
• Flash Point: 98.562 °C
• PSA: 33.12000
• Density: 1.092 g/cm³
• LogP: 0.88230
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

99% ^*data from raw suppliers

(2-Methylpyridin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1)CO

Technology Process of (2-Methylpyridin-4-yl)methanol

There total 17 articles about (2-Methylpyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ (2-methylpyridin-4-yl)methanol (105250-16-6) + 2-methyl-isonicotinic acid amide (19354-04-2)

Guidance literature:

Reference yield: 96.0%

2-methylisonicotinic acid (4021-11-8) → (2-methylpyridin-4-yl)methanol (105250-16-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1021/jacs.7b12768

Reference yield: 94.0%

acetic acid 2-methyl-pyridin-4-ylmethyl ester (55485-90-0) → (2-methylpyridin-4-yl)methanol (105250-16-6)

Guidance literature:

With methanol; ammonia; water; at 20 ℃; for 24h;

upstream raw materials:

2,4-dimethylpyridine N-oxide

acetic anhydride

methanol

2-methyl-pyridine-4-carbaldehyde

Downstream raw materials:

2-methyl-pyridin-4-ylmethyl chloride

1,1,1-trifluoro-2-{1-[3-(4-fluorophenyl)-2-hydroxymethylindolizin-7-ylmethyl]-1H-[1,2,3]triazol-4-yl}butan-2-ol

3-(4-fluorophenyl)-7-hydroxymethylindolizine-2-carboxylic acid ethyl ester

3-(4-fluorophenyl)-7-methanesulfonyloxymethylindolizine-2-carboxylic acid ethyl ester

Refernces

• 1、 -. "QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITOR, COMPOSITIONS, METHODS OF MAKING THEM AND THEIR USE". Page/Page column 547. . Retrieved 2020/05/13.
• 2、 Porter, Jacob D.,Vivas, Oscar,Weaver, C. David,Alsafran, Abdulmohsen,DiMilo, Elliot,Arnold, Leggy A.,Dickson, Eamonn J.,Dockendorff, Chris. "An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders". supporting information. . Retrieved 2019/11/11.