1-(2-Bromophenylsulfonyl)pyrrolidine

Base Information

• Chemical Name: 1-(2-Bromophenylsulfonyl)pyrrolidine
• CAS No.: 929000-58-8
• Molecular Formula: C10H12BrNO2S
• Molecular Weight: 290.181
• Hs Code.: 2935009090
• Mol file: 929000-58-8.mol

Synonyms:1-(2-Bromophenylsulfonyl)pyrrolidine

Chemical Property of 1-(2-Bromophenylsulfonyl)pyrrolidine

Chemical Property:

• Boiling Point: 393.4±44.0 °C(Predicted)
• PKA: -5.61±0.20(Predicted)
• PSA: 45.76000
• Density: 1.583±0.06 g/cm3(Predicted)
• LogP: 3.25230
• Storage Temp.: 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

1-(2-Bromophenylsulfonyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Bromophenylsulfonyl)pyrrolidine

There total 2 articles about 1-(2-Bromophenylsulfonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + o-bromobenzenesulfonyl chloride (2905-25-1) → 1-((2-bromophenyl)sulfonyl)pyrrolidine (929000-58-8)

Guidance literature:

In 1,4-dioxane; at 10 ℃;

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1-((2-bromophenyl)sulfonyl)pyrrolidine (929000-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With chlorosulfonic acid; triethylamine; In dichloromethane;

DOI:10.1002/adsc.201300795

Reference yield: 69.0%

1-((2-bromophenyl)sulfonyl)pyrrolidine (929000-58-8) + 4-formylphenylboronic acid, (87199-17-5) → 2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-carbaldehyde (1202647-49-1)

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,2-dimethoxyethane; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/jm2006035

upstream raw materials:

pyrrolidine

o-bromobenzenesulfonyl chloride

bromobenzene

Downstream raw materials:

[2'-(Pyrrolidine-1-sulfonyl)-biphenyl-4-ylmethyl]-(tetrahydro-pyran-4-yl)-amine

((S)-2-Methoxy-1-methyl-ethyl)-[2'-(pyrrolidine-1-sulfonyl)-biphenyl-4-ylmethyl]-amine

C₂₃H₃₀N₂O₃S

N,N-dimethyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)ethane-1,2-diamine

Refernces

• 1、 Bheeter, Charles B.,Jin, Rongwei,Bera, Jitendra K.,Dixneuf, Pierre H.,Doucet, Henri. "Palladium-catalysed dehydrogenative sp3 C-H bonds functionalisation into alkenes: A direct access to N-alkenylbenzenesulfonamides". supporting information. p. 119 - 124. Retrieved 2014/03/21.