methyl6-chloropyridazine-4-carboxylate

Base Information

• Chemical Name: methyl6-chloropyridazine-4-carboxylate
• CAS No.: 1093860-48-0
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.571
• Hs Code.: 2933990090
• Mol file: 1093860-48-0.mol

Synonyms:6-Chloro-pyridazine-4-carboxylic acid methyl ester;

Chemical Property of methyl6-chloropyridazine-4-carboxylate

Chemical Property:

• Boiling Point: 326.9±22.0 °C(Predicted)
• PKA: -1.33±0.10(Predicted)
• PSA: 52.08000
• Density: 1.372±0.06 g/cm3(Predicted)
• LogP: 0.91660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl6-chloropyridazine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-chloropyridazine-4-carboxylate

Technology Process of methyl6-chloropyridazine-4-carboxylate

There total 2 articles about methyl6-chloropyridazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

6-chloropyridazine-4-carboxylic acid (1256794-24-7) + (diazomethyl)-trimethylsilane → methyl 6-chloropyridazine-4-carboxylate (1093860-48-0)

Guidance literature:

In methanol; hexane; dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 6-chloropyridazine-4-carboxylic acid (1256794-24-7) → methyl 6-chloropyridazine-4-carboxylate (1093860-48-0)

Guidance literature:

In diethyl ether; dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

Reference yield: 79.0%

methyl 6-chloropyridazine-4-carboxylate (1093860-48-0) → 6-chloropyridazine-4-carboxylic acid (1256794-24-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; for 1.5h;

upstream raw materials:

diazomethane

6-chloropyridazine-4-carboxylic acid

Downstream raw materials:

6-chloropyridazine-4-carboxylic acid

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINE AS MALT-1 INHIBITORS". Page/Page column 88. . Retrieved 2019/01/06.