2-Bromo-4,6-Difluoronitrobenzene

Base Information

• Chemical Name: 2-Bromo-4,6-Difluoronitrobenzene
• CAS No.: 884494-38-6
• Molecular Formula: C6H2BrF2NO2
• Molecular Weight: 237.988
• Hs Code.: 2904909090
• Mol file: 884494-38-6.mol

Synonyms:2-BROMO-4,6-DIFLUORONITROBENZENE;

Chemical Property of 2-Bromo-4,6-Difluoronitrobenzene

Chemical Property:

• Vapor Pressure: 0.12mmHg at 25°C
• Boiling Point: 226.9oC at 760 mmHg
• Flash Point: 91oC
• PSA: 45.82000
• Density: 1.89g/cm3
• LogP: 3.15870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-4,6-difluoronitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4,6-Difluoronitrobenzene

There total 1 articles about 2-Bromo-4,6-Difluoronitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-difluorobromobenzene (461-96-1) → 1-bromo-3,5-difluoro-2-nitrobenzene (884494-38-6)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1021/jm800318d

Reference yield: 81.0%

1-bromo-3,5-difluoro-2-nitrobenzene (884494-38-6) + tert-butylamine (75-64-9) → N-tert-butyl-3-bromo-5-fluoro-2-nitrobenzenamine (1052686-61-9)

Guidance literature:

In 1,4-dioxane; at 65 ℃; for 5h; regioselective reaction;

DOI:10.1021/jm800318d

Reference yield: 74.0%

1-bromo-3,5-difluoro-2-nitrobenzene (884494-38-6) + methylamine (74-89-5) → 3-bromo-5-fluoro-N-methyl-2-nitroaniline

Guidance literature:

In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.75h;

upstream raw materials:

3,5-difluorobromobenzene

Downstream raw materials:

N-tert-butyl-3-bromo-5-fluoro-2-nitrobenzenamine

Refernces

• 1、 -. "PYRAZOLYLAMINOBENZIMIDAZOLE DERIVATIVES AS JAK INHIBITORS". Page/Page column 13. . Retrieved 2018/03/26.
• 2、 Charifson, Paul S.,Grillot, Anne-Laure,Grossman, Trudy H.,Parsons, Jonathan D.,Badia, Michael,Bellon, Steve,Deininger, David D.,Drumm, Joseph E.,Gross, Christian H.,LeTiran, Arnaud,Liao, Yusheng,Mani, Nagraj,Nicolau, David P.,Perola, Emanuele,Ronkin, Steven,Shannon, Dean,Swenson, Lora L.,Tang, Qing,Tessier, Pamela R.,Tian, Ski-Kai,Trudeau, Martin,Wang, Tiansheng,Wei, Yunyi,Zhang, Hong,Stamos, Dean. "Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and stucture-activity relationships". experimental part. p. 5243 - 5263. Retrieved 2009/07/01.