N-methylpyrazin-2-amine

Base Information

• Chemical Name: N-methylpyrazin-2-amine
• CAS No.: 32111-28-7
• Molecular Formula: C5H7N3
• Molecular Weight: 109.12900
• Hs Code.: 2933990090
• European Community (EC) Number: 830-137-9
• DSSTox Substance ID: DTXSID50587997
• Nikkaji Number: J346.754F
• Wikidata: Q82480473
• Mol file: 32111-28-7.mol

Synonyms:N-methylpyrazin-2-amine;32111-28-7;N-Methyl-2-pyrazinamine;Methyl-pyrazin-2-yl-amine;MFCD08456680;2-methylaminopyrazine;methylpyrazin-2-yl-amine;SCHEMBL85287;SCHEMBL20229700;SCHEMBL20747588;DTXSID50587997;VGKOARVVEXZTPU-UHFFFAOYSA-N;STK694388;AKOS005605847;MCULE-7314044553;N-METHYL-N-(2-PYRAZINYL)AMINE;AM803689;BS-12861;SY107191;DB-000331;CS-0038033;EN300-52228;Z54629801

Chemical Property of N-methylpyrazin-2-amine

Chemical Property:

• Vapor Pressure: 0.172mmHg at 25°C
• Melting Point: 49-50 °C
• Boiling Point: 212.514oC at 760 mmHg
• PKA: 3.26±0.10(Predicted)
• Flash Point: 82.326oC
• PSA: 37.81000
• Density: 1.145g/cm3
• LogP: 0.59130
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 64.7

Purity/Quality:

99% ^*data from raw suppliers

N-Methylpyrazin-2-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC=CN=C1

Technology Process of N-methylpyrazin-2-amine

There total 5 articles about N-methylpyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloropyrazin (14508-49-7) + methylamine (74-89-5) → N-methylpyrazin-2-amine (32111-28-7)

Guidance literature:

at 100 ℃; for 15h;

Reference yield: 97.0%

2-Aminopyrazine (5049-61-6) + methanol (67-56-1) → N-methylpyrazin-2-amine (32111-28-7)

Guidance literature:

With C₁₉H₃₇IrN₄⁽²⁺⁾*2I^(1-); potassium carbonate; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1055/s-0037-1610252

Reference yield: 49.0%

2-Aminopyrazine (5049-61-6) + methyl iodide (74-88-4) → N-methylpyrazin-2-amine (32111-28-7)

Guidance literature:

2-Aminopyrazine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01365

upstream raw materials:

2-chloropyrazin

methylamine

2-Aminopyrazine

methanol

Downstream raw materials:

3,5-dibromo-N-methylpyrazin-2-amine

Refernces

• 1、 Huang, Qi,Qin, Ling,Zard, Samir Z.. "Xanthate-mediated intermolecular alkylation of pyrazines". supporting information. p. 5804 - 5817. Retrieved 2018/09/21.
• 2、 Liang, Ran,Li, Shun,Wang, Rongzhou,Lu, Lei,Li, Feng. "N-Methylation of Amines with Methanol Catalyzed by a Cp?Ir Complex Bearing a Functional 2,2′-Bibenzimidazole Ligand". supporting information. p. 5790 - 5793. Retrieved 2017/11/10.