6-(beta-D-glucopyranosyloxy)-Salicylic acid Methyl ester

Base Information

• Chemical Name: 6-(beta-D-glucopyranosyloxy)-Salicylic acid Methyl ester
• CAS No.: 108124-75-0
• Molecular Formula: C14H18O9
• Molecular Weight: 330.292
• Mol file: 108124-75-0.mol

Synonyms:108124-75-0

Chemical Property of 6-(beta-D-glucopyranosyloxy)-Salicylic acid Methyl ester

Chemical Property:

• Melting Point: 173-176 °C
• Boiling Point: 574.6±50.0 °C(Predicted)
• PKA: 9.23±0.10(Predicted)
• PSA: 145.91000
• Density: 1.551±0.06 g/cm3(Predicted)
• LogP: -1.64250
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-(beta-D-glucopyranosyloxy)-salicylicacidmethylester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(beta-D-glucopyranosyloxy)-Salicylic acid Methyl ester

There total 8 articles about 6-(beta-D-glucopyranosyloxy)-Salicylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pruyanaside B → methyl 2-β-D-glucopyranosyloxy-6-hydroxybenzoate (108124-75-0) + populine + henryoside + D-(-)-salicin (138-52-3)

Guidance literature:

With sodium methylate; In methanol; for 1h; Ambient temperature;

DOI:10.1016/S0031-9422(00)97773-2

Reference yield:

2-acetoxy-6-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester (115485-94-4) → methyl 2-β-D-glucopyranosyloxy-6-hydroxybenzoate (108124-75-0)

Guidance literature:

With methanol; sodium methylate;

DOI:10.1002/ardp.19592920705

Reference yield:

2-acetoxy-6-hydroxy-benzoic acid methyl ester (114223-67-5) → methyl 2-β-D-glucopyranosyloxy-6-hydroxybenzoate (108124-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: silver oxide; quinoline

2: sodium methylate; methanol

With quinoline; methanol; sodium methylate; silver(l) oxide;

DOI:10.1002/ardp.19592920705

upstream raw materials:

2-acetoxy-6-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester

2-acetoxy-6-hydroxy-benzoic acid methyl ester

2,6-Dihydroxybenzoic acid

2-acetoxy-6-hydroxy-benzoic acid

Refernces

• 1、 Shimomura, Hiroko,Sashida, Yutaka,Yoshinari, Kiyoshi. "PHENOLIC GLUCOSIDES FROM THE HEARTWOOD OF PRUNUS GRAYANA". . p. 1499 - 1502. Retrieved 2007/10/02.