7alpha-Hydroxystigmasterol

Base Information

• Chemical Name: 7alpha-Hydroxystigmasterol
• CAS No.: 64998-19-2
• Molecular Formula: C29H48O2
• Molecular Weight: 428.69000
• Mol file: 64998-19-2.mol

Synonyms:24S-OHC;Cholest-5-ene-3,24-diol;cholest-5-en-3beta,24S-diol;cerebrosterol;24-hydroxycholesterol;cholest-5-ene-3b,24a-diol;24S-hydroxy-cholesterol;

Chemical Property of 7alpha-Hydroxystigmasterol

Chemical Property:

• PSA: 40.46000
• LogP: 6.77160

Purity/Quality:

98%min ^*data from raw suppliers

7α-Hydroxystigmasterol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7alpha-Hydroxystigmasterol

There total 13 articles about 7alpha-Hydroxystigmasterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

3β-acetoxy-(24S)-stigmasta-5,22E-dien-7-one (33028-07-8) → (22E,24S)-stigmasta-5,22-dien-3β,7α-diol (64998-19-2) + (24S)-stigmasta-5,22E-diene-3β,7β-diol (64998-20-5) + Acetic acid (3S,8S,9S,10R,13R,14S,17R)-17-((E)-(1R,4S)-4-ethyl-1,5-dimethyl-hex-2-enyl)-7-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:

With sodium tetrahydroborate; In 1,4-dioxane; methanol; for 18h;

DOI:10.1007/BF01373854

Reference yield:

3β-acetoxy-(24S)-stigmasta-5,22E-dien-7-one (33028-07-8) → (22E,24S)-stigmasta-5,22-dien-3β,7α-diol (64998-19-2) + (24S)-stigmasta-5,22E-diene-3β,7β-diol (64998-20-5)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol;

Reference yield:

acetic acid stigmasteryl ester (4651-48-3,4651-49-4,54482-54-1,75082-06-3,80735-62-2) → (22E,24S)-stigmasta-5,22-dien-3β,7α-diol (64998-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃; acetic acid

2: aluminium isopropylate; isopropyl alcohol

With chromium(VI) oxide; aluminum isopropoxide; acetic acid; isopropyl alcohol;

upstream raw materials:

stigmasterol

3β-acetoxy-(24S)-stigmasta-5,22E-dien-7-one

diethyl ether

Stigmasterol

Refernces

• 1、 Kovganko, N. V.,Chernov, Yu. G.. "Synthesis of 7-oxo- and 7-hydroxy-derivatives of stigmasterol". . p. 183 - 186. Retrieved 2007/10/03.