8(14),15-Isopimaradiene-3,18-diol

Base Information

• Chemical Name: 8(14),15-Isopimaradiene-3,18-diol
• CAS No.: 59219-64-6
• Molecular Formula: C20H32O2
• Molecular Weight: 304.46700
• Mol file: 59219-64-6.mol

Synonyms:sandaracopimaradienediol;Pilsicainide HCl;Pilzicainide;pilsicainide;

Chemical Property of 8(14),15-Isopimaradiene-3,18-diol

Chemical Property:

• Melting Point: 151 °C(Solv: benzene (71-43-2))
• Boiling Point: 416.6±45.0 °C(Predicted)
• PKA: 14.90±0.70(Predicted)
• PSA: 40.46000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 4.08470

Purity/Quality:

98%min ^*data from raw suppliers

8(14),15-Isopimaradiene-3,18-diol ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8(14),15-Isopimaradiene-3,18-diol

There total 2 articles about 8(14),15-Isopimaradiene-3,18-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sandaracopimaradiene-3β,18-diol diacetate (20084-95-1,65894-45-3,82521-47-9,100668-53-9,104117-58-0,107660-89-9) → isopimara-8(14),15-diene-3β,18-diol (59219-64-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1007/BF00714911

Reference yield:

(1S,2S,4aR,4bS,7R,10aR)-2-Acetoxy-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid methyl ester → isopimara-8(14),15-diene-3β,18-diol (59219-64-6)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/0031-9422(72)80062-1

Reference yield:

isopimara-8(14),15-diene-3β,18-diol (59219-64-6) → sandaracopimaradien-3β-ol (4728-30-7)

Guidance literature:

Multistep reaction; (i) aq. CrO₃, Py, (ii) N₂H₄*H₂O, KOH, diethylene glycol;

DOI:10.1039/jr9630000644

upstream raw materials:

sandaracopimaradiene-3β,18-diol diacetate

Downstream raw materials:

sandaracopimaradien-3β-ol

Refernces

• 1、 Raldugin, V. A.,Demenkova, L. I.,Pentegova, V. A.. "Labdane acids and other components of the needles of Pinus pumila". . p. 192 - 197. Retrieved 2007/10/02.