(AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE

Base Information

• Chemical Name: (AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE
• CAS No.: 244277-89-2
• Molecular Formula: C₂₄H₃₆N₂O₂
• Molecular Weight: 384.562
• Mol file: 244277-89-2.mol

Synonyms:

Chemical Property of (AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE

Chemical Property:

• Storage Temp.: Store at +4°C

Purity/Quality:

99% ^*data from raw suppliers

J 104129 Fumarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: J 104129 is a mAChR M3 antagonist.

Technology Process of (AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE

There total 21 articles about (AR)-A-CYCLOPENTYL-A-HYDROXY-N-[1-(4-METHYL-3-PENTENYL)-4-PIPERIDINYL]BENZENEACETAMIDE FUMARATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid (64471-45-0) + 4-amino-1-(4-methyl-3-pentenyl)piperidine dihydrochloride → J 104129 (244277-89-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00327-3

Reference yield: 59.0%

2-cyclopentyl-2-hydroxy-2-phenylacetic acid (427-49-6) + 1-(4-methyl-3-pentenyl)-4-aminopiperidine (185030-43-7) → (+/-)-J 104129 (244277-89-2)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃;

DOI:10.1016/S0968-0896(99)00177-7

Reference yield:

cyclopent-2-enone (930-30-3) → J 104129 (244277-89-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) LDA

2: 60 percent / H₂ / 10 percent Pd/C, AcONa / methanol

3: aq. NaOH / methanol

4: 72 percent / CDI, i-Pr₂NEt / dimethylformamide

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; palladium on activated charcoal; sodium acetate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00327-3

upstream raw materials:

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-(4-methyl-3-pentenyl)-4-aminopiperidine

1-(4-methyl-3-pentenyl)-4-piperidone

1-bromo-4-methylpent-3-ene

Refernces

• 1、 Mitsuya, Morihiro,Mase, Toshiaki,Tsuchiya, Yoshimi,Kawakami, Kumiko,Hattori, Hiromi,Kobayashi, Kensuke,Ogino, Yoshio,Fujikawa, Toru,Satoh, Akio,Kimura, Toshifumi,Noguchi, Kazuhito,Ohtake, Norikazu,Tomimoto, Koji. "J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors". . p. 2555 - 2567. Retrieved 2007/10/03.