2-Bromo-5-chlorobenzyl alcohol

Base Information

• Chemical Name: 2-Bromo-5-chlorobenzyl alcohol
• CAS No.: 60666-70-8
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Hs Code.: 2906299090
• Mol file: 60666-70-8.mol

Synonyms:Benzenemethanol, 2-bromo-5-chloro-;

Chemical Property of 2-Bromo-5-chlorobenzyl alcohol

Chemical Property:

• Vapor Pressure: 0.000972mmHg at 25°C
• Melting Point: 81-83 °C
• Refractive Index: 1.605
• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 129.3 °C
• PSA: 20.23000
• Density: 1.685 g/cm³
• LogP: 2.59480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-5-chlorobenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-5-chlorobenzyl Alcohol is used to prepare fluorodihydrohydroxy benzoxaborole for potential treatment of onychomycosis. It is also an intermediate used to synthesize morpholylureas as potent and selective inhibitors of AKR1C3.

Technology Process of 2-Bromo-5-chlorobenzyl alcohol

There total 5 articles about 2-Bromo-5-chlorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-chlorobenzoic acid (21739-93-5) → 2-bromo-5-chlorobenzyl alcohol (60666-70-8)

Guidance literature:

With borane-THF; at 10 - 20 ℃; Inert atmosphere;

Reference yield: 100.0%

2-bromo-5-chlorobenzaldehyde (174265-12-4) → 2-bromo-5-chlorobenzyl alcohol (60666-70-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

methyl-2-bromo-5-chlorobenzoate (27007-53-0) → 2-bromo-5-chlorobenzyl alcohol (60666-70-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 4h;

upstream raw materials:

2-bromo-5-chlorobenzoic acid

methyl-2-bromo-5-chlorobenzoate

2-bromo-5-chlorobenzaldehyde

5-chloroanthranilic acid

Downstream raw materials:

2-bromo-5-chloro-1-(methoxymethoxymethyl)benzene

1-bromo-4-chloro-2-(fluoromethyl)benzene

Refernces

• 1、 -. "Synthesis method of citalopram intermediate". Paragraph 0055-0056. . Retrieved 2020/08/25.
• 2、 Abengózar, Alberto,García-García, Patricia,Sucunza, David,Pérez-Redondo, Adrián,Vaquero, Juan J.. "Synthesis of functionalized helical BN-benzo[c] phenanthrenes". supporting information. p. 2467 - 2470. Retrieved 2018/03/21.