METHYL 2-HYDROXYDODECANOATE

Base Information

• Chemical Name: METHYL 2-HYDROXYDODECANOATE
• CAS No.: 51067-85-7
• Molecular Formula: C₁₃H₂₆O₃
• Molecular Weight: 230.348
• Hs Code.: 2918199090
• Mol file: 51067-85-7.mol

Synonyms:METHYL 2-HYDROXYDODECANOATE;DL-ALPHA-HYDROXYLAURIC ACID METHYL ESTER;2-HYDROXY C12:0 METHYL ESTER;2-HYDROXY C14:0 METHYL ESTER;dl-A-hydroxylauric acid methyl ester;dl-α-hydroxylauric acid methyl ester;2-Hydroxydodecanoic acid methyl ester

Chemical Property of METHYL 2-HYDROXYDODECANOATE

Chemical Property:

• Vapor Pressure: 0.000568mmHg at 25°C
• Refractive Index: 1.448
• Boiling Point: 277.2°C at 760 mmHg
• Flash Point: 118.5°C
• PSA: 46.53000
• Density: 0.942g/cm³
• LogP: 3.05110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-hydroxy Lauric Acid methyl ester ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-HYDROXYDODECANOATE

There total 3 articles about METHYL 2-HYDROXYDODECANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1,1,1-tris(methylthio)-2-dodecanol (124838-36-4) → 2-hydroxydodecanoic acid methyl ester (51067-85-7)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In methanol; for 1h; Heating;

DOI:10.1246/bcsj.62.2013

Reference yield:

undecylaldehyde (112-44-7) → 2-hydroxydodecanoic acid methyl ester (51067-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / 1.) nBuLi / tetrahydrofuran; hexane / 1.) N₂ atm., -78 degC, 15 min; 2.) -78 degC, 1 h then r.t., 1 h

2: 77 percent / HgCl₂, HgO / methanol / 1 h / Heating

With n-butyllithium; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; methanol; hexane;

DOI:10.1246/bcsj.62.2013

Reference yield:

2-methoxy-dodecanoic acid methyl ester (18797-16-5) → 2-hydroxydodecanoic acid methyl ester (51067-85-7)

Guidance literature:

With methanol; boron trifluoride; at 80 ℃; for 0.0833333h;

DOI:10.1021/jf800647w

upstream raw materials:

1,1,1-tris(methylthio)-2-dodecanol

undecylaldehyde

2-methoxy-dodecanoic acid methyl ester

Downstream raw materials:

C₂₀H₂₅F₅O₄

Refernces

• 1、 Orito, Kazuhiko,Seki, Yoshikatsu,Suginome, Hiroshi,Iwadare, Tsukasa. "Synthesis of S-Methyl 2-Hydrxyalkanethioates, 2-Hydroxyalkanoic Acids and Related Compounds via the Addition Reaction of Tris(methylthio)methanide Ion to Alkanals". . p. 2013 - 2017. Retrieved 2007/10/02.