Purmorphamine

Base Information

• Chemical Name: Purmorphamine
• CAS No.: 483367-10-8
• Molecular Formula: C31H32N6O2
• Molecular Weight: 520.62
• NSC Number: 747596
• UNII: PB12M2F8KY
• DSSTox Substance ID: DTXSID20415293
• Nikkaji Number: J1.850.435I
• Wikipedia: Purmorphamine
• Wikidata: Q15409344
• Metabolomics Workbench ID: 62573
• ChEMBL ID: CHEMBL1221984
• Mol file: 483367-10-8.mol

Synonyms:purmorphamine

Chemical Property of Purmorphamine

Chemical Property:

• Appearance/Colour: Light Tan Solid
• Melting Point: 210-212 °C
• Boiling Point: 790.313 °C at 760 mmHg
• PKA: 5.44±0.40(Predicted)
• Flash Point: 431.766 °C
• PSA: 77.33000
• Density: 1.353 g/cm³
• LogP: 6.99520
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)
• XLogP3: 6.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 520.25867428
• Heavy Atom Count: 39
• Complexity: 768

Purity/Quality:

98%,99%, ^*data from raw suppliers

Purmorphamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7
• Description: Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 μM. Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.
• Uses: An activator of the hedgehog (Hh) signaling pathway. Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish. Activates the Hedgehog pathway by targeting Smoothened