1-PHENYLBUTANONE-TOSYLHYDRAZONE 97

Base Information

• Chemical Name: 1-PHENYLBUTANONE-TOSYLHYDRAZONE 97
• CAS No.: 41780-81-8
• Molecular Formula: CH3C6H4SO2NHN=C(C6H5)CH2CH2CH3
• Molecular Weight: 316.424
• Hs Code.: 2935009090
• Mol file: 41780-81-8.mol

Synonyms:1-PHENYLBUTANONE-TOSYLHYDRAZONE 97

Chemical Property of 1-PHENYLBUTANONE-TOSYLHYDRAZONE 97

Chemical Property:

• Melting Point: 122-125 °C(lit.)
• PSA: 66.91000
• LogP: 4.75370
• Sensitive.: Air Sensitive

Purity/Quality:

98%Min ^*data from raw suppliers

1-Phenylbutanone-tosylhydrazone 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYLBUTANONE-TOSYLHYDRAZONE 97

There total 2 articles about 1-PHENYLBUTANONE-TOSYLHYDRAZONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethylmagnesium bromide (925-90-6) + N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide (71094-28-5) → 1-phenyl-1-butanone 2-naphthylethanone p-toluenesulfonylhydrazone (41780-81-8)

Guidance literature:

ethylmagnesium bromide; With copper(l) chloride; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja100932q

Reference yield: 78.0%

propiophenone (495-40-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 1-phenyl-1-butanone 2-naphthylethanone p-toluenesulfonylhydrazone (41780-81-8)

Guidance literature:

In methanol; Reflux;

DOI:10.1002/ejoc.201901834

Reference yield: 100.0%

1-phenyl-1-butanone 2-naphthylethanone p-toluenesulfonylhydrazone (41780-81-8) → propiophenone (495-40-9)

Guidance literature:

With copper(II) sulfate; In tetrahydrofuran; methanol; water; for 3h; Heating;

upstream raw materials:

ethylmagnesium bromide

N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide

propiophenone

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

propiophenone

(Z)-1-methyl-2-(1-phenylbut-1-en-1-yl)benzene

4,5-dimethyl-2-(1-phenylbutyl)thiazole

5-methyl-2-(1-phenylbutyl)benzo[d]oxazole

Refernces

• 1、 Reddy Lonka, Madhava,Zhang, Jinquan,Gogula, Thirupathi,Zou, Hongbin. "Copper(i)-catalyzed benzylation of triazolopyridine through direct C-H functionalization". . p. 7455 - 7460. Retrieved 2019/08/20.
• 2、 Gao, Yang,Xiong, Wenfang,Chen, Huoji,Wu, Wanqing,Peng, Jianwen,Gao, Yinglan,Jiang, Huanfeng. "Pd-Catalyzed Highly Regio- and Stereoselective Formation of C-C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes". . p. 7456 - 7467. Retrieved 2015/08/18.