4-(2,2-Difluorocyclopropyl)-toluene

Base Information

• Chemical Name: 4-(2,2-Difluorocyclopropyl)-toluene
• CAS No.: 54672-44-5
• Molecular Formula: C10H10F2
• Molecular Weight: 168.186
• Hs Code.: 2903999090
• Mol file: 54672-44-5.mol

Synonyms:1-(2,2-Difluorocyclopropyl)-4-methyl-benzene;

Chemical Property of 4-(2,2-Difluorocyclopropyl)-toluene

Chemical Property:

• Vapor Pressure: 0.345mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 206.2 °C at 760 mmHg
• Flash Point: 63.2 °C
• PSA: 0.00000
• Density: 1.13 g/cm³
• LogP: 3.11760

Purity/Quality:

98%min ^*data from raw suppliers

4-(2,2-DIFLUOROCYCLOPROPYL)TOLUENE 98.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of 4-(2,2-Difluorocyclopropyl)-toluene

There total 3 articles about 4-(2,2-Difluorocyclopropyl)-toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,2‐difluoro‐2‐(triphenylphosphonio)acetate + 4-n-methylphenylacetylene (766-97-2) → 1,1-Difluor-2-p-tolylcyclopropan (54672-44-5)

Guidance literature:

In dimethyl sulfoxide; at 110 ℃; for 8h; Sealed tube;

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1,1-Difluor-2-p-tolylcyclopropan (54672-44-5)

Guidance literature:

With sodium iodide; In tetrahydrofuran; at 65 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b01897

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + phenyl(trifluoromethyl)mercury (24925-18-6) → 1,1-Difluor-2-p-tolylcyclopropan (54672-44-5)

Guidance literature:

With sodium iodide;

DOI:10.1021/ja00835a020

upstream raw materials:

1-ethenyl-4-methylbenzene

phenyl(trifluoromethyl)mercury

4-n-methylphenylacetylene

(trifluoromethyl)trimethylsilane

Refernces

• 1、 Jiang, Zhong-Tao,Huang, Jiangkun,Zeng, Yaxin,Hu, Fangdong,Xia, Ying. "Rhodium Catalyzed Regioselective C?H Allylation of Simple Arenes via C?C Bond Activation of Gem-difluorinated Cyclopropanes". supporting information. p. 10626 - 10631. Retrieved 2021/04/05.
• 2、 Ni, Jiabin,Nishonov, Bekzod,Pardaev, Azizbek,Zhang, Ao. "Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones". . p. 13646 - 13654. Retrieved 2019/11/11.