Imatinib (Piperidine)-N-oxide

Base Information

• Chemical Name: Imatinib (Piperidine)-N-oxide
• CAS No.: 571186-91-9
• Molecular Formula: C29H31N7O2
• Molecular Weight: 509.611
• Hs Code.: 29333990
• Mol file: 571186-91-9.mol

Synonyms:4-[(4-Methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;CGP 71422;Imatinib (Piperidine)-N-oxide

Chemical Property of Imatinib (Piperidine)-N-oxide

Chemical Property:

• Melting Point: 146-149°C
• PKA: 13.23±0.70(Predicted)
• PSA: 118.13000
• LogP: 4.85980
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imatinib(Piperazine)-4-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Imatinib (Piperidine)-4-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity D. Imatinib (Piperidine)-4-oxide (Imatinib EP Impurity J) is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity D. It is a COVID19-related research product. A metabolite of Imatinib

Technology Process of Imatinib (Piperidine)-N-oxide

There total 1 articles about Imatinib (Piperidine)-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imatinib (152459-95-5) → CGP 71422 (571186-91-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -20 - 20 ℃; for 72h;

DOI:10.1016/j.bmc.2013.03.038

upstream raw materials:

imatinib

Refernces

• 1、 Manley, Paul W.,Blasco, Francesca,Mestan, Jürgen,Aichholz, Reiner. "The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588". . p. 3231 - 3239. Retrieved 2013/07/11.