(2-Ethylphenyl)hydrazine

Base Information

• Chemical Name: (2-Ethylphenyl)hydrazine
• CAS No.: 19398-06-2
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.658
• Hs Code.: 29280000
• DSSTox Substance ID: DTXSID10941096
• Nikkaji Number: J1.890.705D
• Wikidata: Q72476686
• Mol file: 19398-06-2.mol

Synonyms:(2-ethylphenyl)hydrazine;19275-55-9;2-ethylphenylhydrazine;Hydrazine, (2-ethylphenyl)-;(2-Ethyl-phenyl)-hydrazine;2-Ethylphenylhydrazinehydrochloride;(2-Ethylphenyl)-Hydrazine;1-(2-ethylphenyl)hydrazine;Oprea1_325783;SCHEMBL844631;DTXSID10941096;BBL020463;STK397820;AKOS000158008;A8297;BB 0249753;CS-0449465;FT-0726311

Chemical Property of (2-Ethylphenyl)hydrazine

Chemical Property:

• Appearance/Colour: almost white to beige fluffy powder
• Vapor Pressure: 0.0253mmHg at 25°C
• Melting Point: 178 °C (dec.)(lit.)
• Refractive Index: 1.603
• Boiling Point: 247.7 °C at 760 mmHg
• Flash Point: 118.9 °C
• PSA: 38.05000
• Density: 1.056g/cm3
• LogP: 3.10990
• Sensitive.: Hygroscopic
• Solubility.: water: soluble
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 93.3

Purity/Quality:

99% ^*data from raw suppliers

2-Ethylphenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn; N
• Hazard Codes: Xn,N,T
• Statements: 22-36/37/38-43-50/53-48/25-41-40
• Safety Statements: 26-36/37-60-61-45-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC1=CC=CC=C1NN

Technology Process of (2-Ethylphenyl)hydrazine

There total 2 articles about (2-Ethylphenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ortho-ethylaniline (578-54-1) → 2-ethylphenylhydrazine hydrochloride (19398-06-2,58711-02-7)

Guidance literature:

ortho-ethylaniline; With hydrogenchloride; sodium nitrite; In water; at 25 ℃; for 0.00416667h; Flow reactor; Large scale;

With sodium sulfite; In water; at 25 - 100 ℃; for 0.508333h; Flow reactor; Large scale;

With hydrogenchloride; In water; toluene; at 100 ℃; Temperature; Flow reactor; Large scale;

DOI:10.1021/acs.oprd.5b00115

Reference yield:

→ 2-ethylphenylhydrazine hydrochloride (19398-06-2,58711-02-7)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

DOI:10.1021/jo01110a004

Reference yield: 94.0%

3-Aminocrotononitrile (1118-61-2) + 2-ethylphenylhydrazine hydrochloride (19398-06-2,58711-02-7) → 3-methyl-1-(2-ethylphenyl)-1H-pyrazol-5-amine (1020703-66-5)

Guidance literature:

3-Aminocrotononitrile; 2-ethylphenylhydrazine hydrochloride; With hydrogenchloride; In water; at 100 ℃; for 18h;

With sodium hydroxide; In water; pH=> 12;

upstream raw materials:

ortho-ethylaniline

Downstream raw materials:

7-ethyl-2-(1H-indol-3-yl)ethan-1-ol

(8-ethyl-1-methoxycarbonylmethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid methyl ester

1-(3-bromopropyl)-8-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carbonitrile

8-ethyl-1-(3-hydroxypropyl)-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carbonitrile

Refernces

• 1、 Pagire, Suvarna H.,Lee, Eunhye,Pagire, Haushabhau S.,Bae, Eun Jung,Ryu, Soo Jung,Lee, Dahye,Kim, Min Hee,Kim, Geum Ran,Hwang, Kyu-Seok,Ahn, Sukyung,Maeng, Jin Hee,Song, Jin Sook,Bae, Myung Ae,Lee, Don Hang,Ahn, Jin Hee. "Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents". . p. 529 - 532. Retrieved 2018/01/04.
• 2、 -. "Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac". . . Retrieved 2008/06/13.