(R)-2-Amino-3-methylbutanamide hydrochloride

Base Information

• Chemical Name: (R)-2-Amino-3-methylbutanamide hydrochloride
• CAS No.: 133170-58-8
• Molecular Formula: C5H13ClN2O
• Molecular Weight: 152.624
• DSSTox Substance ID: DTXSID60704855
• Mol file: 133170-58-8.mol

Synonyms:133170-58-8;D-Valinamide hydrochloride;(R)-2-Amino-3-methylbutanamide hydrochloride;H-D-VAL-NH2 HCL;H-D-Val-NH2.HCl;H-D-Val-NH2 hydrochloride;(2R)-2-amino-3-methylbutanamide hydrochloride;(2R)-2-amino-3-methylbutanamide;hydrochloride;d-valine amide hydrochloride;D-ValNH2.HCl;H-D-Val-NH2-HCl;MFCD00270619;D-valinamide HCl salt;SCHEMBL2716045;D-Valinamide hydrochloride, 97%;DTXSID60704855;XFCNYSGKNAWXFL-PGMHMLKASA-N;Butanamide, 2-amino-3-methyl-, hydrochloride (1:1), (2R)-;AKOS015919718;CS-W002589;D-Valinamide--hydrogen chloride (1/1);AS-70316;BP-10417;(R)-2-AMINO-3-METHYLBUTANAMIDE HCL;EN300-213882;A888177;Z1198153018

Chemical Property of (R)-2-Amino-3-methylbutanamide hydrochloride

Chemical Property:

• PSA: 69.11000
• LogP: 1.65760
• Storage Temp.: Store at 0°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 152.0716407
• Heavy Atom Count: 9
• Complexity: 90.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Valine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)N)N.Cl
• Isomeric SMILES: CC(C)[C@H](C(=O)N)N.Cl
• Uses: D-Valinamide hydrochloride is a useful reactant for the preparation of a variety compounds and complexes such as lanthanide(III) complexes and carbamate analogs of fumagillin.

Technology Process of (R)-2-Amino-3-methylbutanamide hydrochloride

There total 7 articles about (R)-2-Amino-3-methylbutanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ D-valine amide hydrochloride (133170-58-8)

Guidance literature:

Reference yield:

2-(1,3-dicyano-5-isopropenyl-2-methyl-cyclohexylamino)-3-methyl-butyramide → (S)-2-amino-3-methylbutanamide hydrochloride (3014-80-0) + D-valine amide hydrochloride (133170-58-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=1; Title compound not separated from byproducts;

DOI:10.1002/ejoc.200600294

Reference yield:

L-valinamide (4540-60-7,20108-78-5) → D-valine amide hydrochloride (133170-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / ethanol / 120 h / Heating

2: water / 36 h / Heating

With water; In ethanol;

DOI:10.1002/ejoc.200600294

upstream raw materials:

9-isopropenyl-2-isopropyl-6-methyl-3-oxo-1,4-diaza-spiro[4.5]decane-7-carbonitrile

L-valinamide

(S)-2-amino-3-methylbutanenitrile

(1R,2R,3R,5R)-1-((S)-1-Cyano-2-methyl-propylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

Downstream raw materials:

N-(1-amino-3-methyl-1-oxobutan-2-yl)-4-methoxybenzamide

D-valine amide

(R)-2-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-6-(1-amino-3-methyl-1-oxobutan-2-ylamino)-5-cyanonicotinamide

Refernces

• 1、 Rossi, Jean-Christophe,Marull, Marc,Boiteau, Laurent,Taillades, Jacques. "Regioselective hydration and deprotection of chiral, dissymmetric iminodinitriles in the scope of an asymmetric strecker strategy". . p. 662 - 668. Retrieved 2007/10/03.
• 2、 -. "THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS". Page 230. . Retrieved 2008/06/13.