Technology Process of (S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester
There total 8 articles about (S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)acetic acid;
With
piperidine; rink amide linker modified polystyrene grafted crowns; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
ketoprofen chloride;
With
triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 12h;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.666667h;
Further stages.;
DOI:10.1021/jo010425j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 80 percent / NH3 aq. / H2O / 9 h / 230 °C
2.1: 96 percent / sodium hydride / tetrahydrofuran / 12 h / 20 °C
3.1: 100 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C
4.1: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 12 h / 20 °C
5.1: 95 percent / Na2CO3 / methanol; H2O / 1.5 h / 20 °C
6.1: 100 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
7.1: rink amide linker modified polystyrene grafted crowns; piperidine; benzotriazolyloxy-tris(dimethylamino)phosphonium(1+) PF6(1-) / diisopropylethylamine / dimethylformamide / 12 h / 20 °C
7.2: triethylamine / tetrahydrofuran / 12 h / 0 °C
7.3: 104 mg / trifluoroacetic acid / CH2Cl2 / 0.67 h
With
piperidine; dmap; ammonium hydroxide; rink amide linker modified polystyrene grafted crowns; hydrogen; sodium hydride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo010425j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl chloride / 12 h / 40 °C
2.1: rink amide linker modified polystyrene grafted crowns; piperidine; benzotriazolyloxy-tris(dimethylamino)phosphonium(1+) PF6(1-) / diisopropylethylamine / dimethylformamide / 12 h / 20 °C
2.2: triethylamine / tetrahydrofuran / 12 h / 0 °C
2.3: 104 mg / trifluoroacetic acid / CH2Cl2 / 0.67 h
With
piperidine; oxalyl dichloride; rink amide linker modified polystyrene grafted crowns; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo010425j
