3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE
• CAS No.: 122745-12-4
• Molecular Formula: C₁₃H₁₃NO₂*ClH
• Molecular Weight: 251.713
• Hs Code.: 2922499990
• Mol file: 122745-12-4.mol

Synonyms:2-Naphthalenepropanoicacid, a-amino-, hydrochloride, (S)-;2-Naphthalenepropanoic acid, a-amino-, hydrochloride, (aS)- (9CI);

Chemical Property of 3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE

Chemical Property:

• PSA: 63.32000
• LogP: 3.29650
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Naphthyl)-L-alanine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE

There total 3 articles about 3-(2-NAPHTHYL)-L-ALANINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-acetylamino-2-cyano-3-(naphthalen-2-yl)propanoate (143218-07-9) → 2-Amino-3-naphthalen-2-yl-propionic acid; hydrochloride (63024-44-2,122745-11-3,122745-12-4)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

DOI:10.1021/jm00096a010

Reference yield:

2-bromomethylnaphthyl bromide (939-26-4) → 2-Amino-3-naphthalen-2-yl-propionic acid; hydrochloride (63024-44-2,122745-11-3,122745-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuOK / 2-methyl-propan-2-ol / 24 h / 20 °C

2: 79 percent / 20percent aq. HCl / 30 h / Heating

With hydrogenchloride; potassium tert-butylate; In tert-butyl alcohol;

DOI:10.1021/jm00096a010

Reference yield:

tert-butyl 2-((diphenylmethylene)amino)-3-(naphthalen-2-yl)propanoate → 2-Amino-3-naphthalen-2-yl-propionic acid; hydrochloride (63024-44-2,122745-11-3,122745-12-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃;

DOI:10.1002/chem.201102885

upstream raw materials:

ethyl 2-acetylamino-2-cyano-3-(naphthalen-2-yl)propanoate

2-bromomethylnaphthyl bromide

Downstream raw materials:

N-tert-butoxycarbonyl-3-(2-naphthyl)-alanine

Refernces

• 1、 Nun, Pierrick,Perez, Violaine,Calmes, Monique,Martinez, Jean,Lamaty, Frederic. "Preparation of chiral amino esters by asymmetric phase-transfer catalyzed alkylations of schiff bases in a ball mill". experimental part. p. 3773 - 3779. Retrieved 2012/04/23.