3-BENZYLOXYCINNAMIC ACID

Base Information

• Chemical Name: 3-BENZYLOXYCINNAMIC ACID
• CAS No.: 122024-75-3
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Hs Code.: 2918990090
• Mol file: 122024-75-3.mol

Synonyms:3-(Benzyloxy)cinnamicacid; m-Benzyloxycinnamic acid

Chemical Property of 3-BENZYLOXYCINNAMIC ACID

Chemical Property:

• PSA: 46.53000
• LogP: 3.36340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(2E)-3-[3-(Benzyloxy)phenyl]prop-2-enoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZYLOXYCINNAMIC ACID

There total 13 articles about 3-BENZYLOXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-(3-benzyloxyphenyl)propenoate (495399-41-2) → C16H14O3 (122024-75-3)

Guidance literature:

methyl 3-(3-benzyloxyphenyl)propenoate; With lithium hydroxide; In water; diethylene glycol; at 90 ℃; for 0.25h; Sonication; Microwave irradiation;

With hydrogenchloride; In water; diethylene glycol;

DOI:10.1080/00397910902738112

Reference yield: 96.0%

malonic acid (141-82-2) + 3-Benzyloxybenzaldehyde (1700-37-4) → 3-<3-(phenylmethoxy)phenyl>-2-propenoic acid (122024-75-3,138835-16-2)

Guidance literature:

With piperidine; pyridine; at 120 ℃; for 3h;

DOI:10.1016/j.ejmech.2019.111723

Reference yield: 96.0%

3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester (208836-69-5) → 3-<3-(phenylmethoxy)phenyl>-2-propenoic acid (122024-75-3,138835-16-2)

Guidance literature:

With barium hydroxide octahydrate; In methanol; at 80 ℃; for 1h; Reflux;

DOI:10.1055/s-0032-1316776

upstream raw materials:

3-hydroxy-trans-cinnamic acid

benzyl bromide

malonic acid

3-Benzyloxybenzaldehyde

Downstream raw materials:

methyl 5-(benzyloxy)-3-chlorobenzo[b]thiophene-2-carboxylate

kb-NB₁₂₃-66

Kb-NB₁₆₅-89

kb-NB142-70

Refernces

• 1、 Xie, Yundong,Liu, Jiping,Shi, Yongheng,Bin Wang,Wang, Xiaoping,Wang, Wei,Sun, Meng,Xu, Xinya,He, Shipeng. "Synthesis and evaluation of new sesamol-based phenolic acid derivatives with hypolipidemic, antioxidant, and hepatoprotective effects". . p. 1688 - 1702. Retrieved 2021/07/26.
• 2、 Chen, Yao,Lin, Hongzhi,Zhu, Jie,Gu, Kai,Li, Qi,He, Siyu,Lu, Xin,Tan, Renxiang,Pei, Yuqiong,Wu, Liang,Bian, Yaoyao,Sun, Haopeng. "Design, synthesis,: In vitro and in vivo evaluation of tacrine-cinnamic acid hybrids as multi-target acetyl- and butyrylcholinesterase inhibitors against Alzheimer's disease". . p. 33851 - 33867. Retrieved 2017/07/17.