CHLOROAC-D-PHE-OH

Base Information

• Chemical Name: CHLOROAC-D-PHE-OH
• CAS No.: 137503-97-0
• Molecular Formula: C11H12ClNO3
• Molecular Weight: 241.674
• Mol file: 137503-97-0.mol

Synonyms:N-(Chloroacetyl)-D-phenylalanine;

Chemical Property of CHLOROAC-D-PHE-OH

Chemical Property:

• Melting Point: 125 °C
• Refractive Index: -49 ° (C=1, EtOH)
• Boiling Point: 482.2 °C at 760 mmHg
• Flash Point: 245.4 °C
• PSA: 66.40000
• Density: 1.312 g/cm³
• LogP: 1.42820
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

CHLOROAC-D-PHE-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHLOROAC-D-PHE-OH

There total 4 articles about CHLOROAC-D-PHE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-chloroacetyl-DL-phenylalanine (7765-11-9) → L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + N-Chloroacetyl-D-phenylalanine (137503-97-0)

Guidance literature:

With carboxypeptidase-substance from bovine pancreas; Hydrolysis;

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → N-Chloroacetyl-D-phenylalanine (137503-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / acetonitrile / 1.5 h / Heating

2: 4 N aq. KOH, 0.10 M potassium phosphate buffer (pH 7.5), 1 mM CoCl₂ / porcine kidney acylase I / 40 °C / relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl₂

With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I; In acetonitrile;

DOI:10.1021/ja00198a055

Reference yield:

N-chloroacetyl-DL-phenylalanine (7765-11-9) → N-Chloroacetyl-D-phenylalanine (137503-97-0)

Guidance literature:

upstream raw materials:

N-chloroacetyl-DL-phenylalanine

Phenylalanine

Downstream raw materials:

D-(R)-phenylalanine

glycyl-D-phenylalanine

(R)-3-benzyl-2,5-piperazinedione

Refernces