4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE
• CAS No.: 122839-50-3
• Molecular Formula: 3C₁₀H₁₀F₃NO₂*ClH
• Molecular Weight: 736.031
• Hs Code.: 2922499990
• Mol file: 122839-50-3.mol

Synonyms:4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE;4-TRIFLUROMETHYL-L-PHENYLALANINE HYDROCHLORIDE;(S)-2-AMINO-3-(4-(TRIFLUOROMETHYL)PHENYL)PROPANOIC ACID;D-PHE(4-CF3)-OH

Chemical Property of 4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 311.5°Cat760mmHg
• Flash Point: 142.2°C
• PSA: 63.32000
• Density: 1.364g/cm³
• LogP: 3.16210

Purity/Quality:

99% ^*data from raw suppliers

H-L-Phe(4-CF3)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE

There total 7 articles about 4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl (R)-2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoate (82317-77-9) → (R)-2-Amino-3-(4-trifluoromethyl-phenyl)-propionic acid; hydrochloride (3832-77-7,82337-63-1,122839-50-3,122839-56-9)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1021/jm00349a006

Reference yield:

2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoic acid (82337-58-4) → (R)-2-Amino-3-(4-trifluoromethyl-phenyl)-propionic acid; hydrochloride (3832-77-7,82337-63-1,122839-50-3,122839-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / BF₃*OEt₂ / 1 h / Heating

3: 91 percent / 6N aq. HCl / 2 h / Heating

With hydrogenchloride; boron trifluoride diethyl etherate;

DOI:10.1021/jm00349a006

Reference yield:

diethyl 2-acetamido-2-<<4-(trifluoromethyl)phenyl>methyl>malonate (114872-59-2) → (R)-2-Amino-3-(4-trifluoromethyl-phenyl)-propionic acid; hydrochloride (3832-77-7,82337-63-1,122839-50-3,122839-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH

2: 89 percent / BF₃*OEt₂ / 1 h / Heating

4: 91 percent / 6N aq. HCl / 2 h / Heating

With hydrogenchloride; sodium hydroxide; boron trifluoride diethyl etherate;

DOI:10.1021/jm00349a006

upstream raw materials:

methyl (R)-2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoate

2-acetamido-3-(4-(trifluoromethyl)phenyl)propanoic acid

diethyl 2-acetamido-2-<<4-(trifluoromethyl)phenyl>methyl>malonate

2-Acetylamino-3-(4-trifluoromethyl-phenyl)-propionic acid methyl ester

Downstream raw materials:

(R)-2-((tert-butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid

Refernces

• 1、 Krause, Hans-Walter,Kreuzfeld, Hans-Joern,Doebler, Christian,Taudien, Stefan. "UNUSUAL AMINO ACIDS II. Asymmetric Synthesis of Fluorine Containing Phenylalanines". . p. 555 - 566. Retrieved 2007/10/02.