1-(5-Aminopyridin-2-yl)ethanone

Base Information

• Chemical Name: 1-(5-Aminopyridin-2-yl)ethanone
• CAS No.: 51460-32-3
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• Mol file: 51460-32-3.mol

Synonyms:1-(5-Aminopyridin-2-yl)ethanone;2-Acetyl-5-aminopyridine;

Chemical Property of 1-(5-Aminopyridin-2-yl)ethanone

Chemical Property:

• Boiling Point: 336.726 °C at 760 mmHg
• PKA: 3.93±0.10(Predicted)
• Flash Point: 157.446 °C
• PSA: 55.98000
• Density: 1.169 g/cm³
• LogP: 1.44760
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Aminopyridin-2-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Aminopyridin-2-yl)ethanone

There total 5 articles about 1-(5-Aminopyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylmagnesium bromide (75-16-1) + 5-amino-2-cyanopyridine (55338-73-3) → 1-(5-aminopyridin-2-yl)ethan-1-one (51460-32-3)

Guidance literature:

methylmagnesium bromide; 5-amino-2-cyanopyridine; In tetrahydrofuran; diethyl ether; at 0 ℃; for 2h;

With water; In tetrahydrofuran; diethyl ether; Further stages.;

DOI:10.1039/b718854d

Reference yield: 53.0%

methylmagnesium chloride (676-58-4) + 5-amino-2-cyanopyridine (55338-73-3) → 1-(5-aminopyridin-2-yl)ethan-1-one (51460-32-3)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 4h;

Reference yield:

2-bromo-5-nitropyridine (4487-59-6) → 1-(5-aminopyridin-2-yl)ethan-1-one (51460-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2 h / 100 °C

2: zinc; ammonium chloride / ethanol / 2 h / 20 °C

3: tetrahydrofuran / 4 h / -78 - 20 °C

With ammonium chloride; zinc; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

methylmagnesium bromide

5-amino-2-cyanopyridine

2-bromo-5-nitropyridine

5-nitropyridine-2-carbonitrile

Downstream raw materials:

2-(2-(2-(2-((6-(1-aminoethyl)pyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

2-(2-(2-(2-((6-acetylpyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

2-(2-((2-((6-acetylpyridin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetamide

1-(2-(2-(2-((6-acetylpyridin-3-yl)amino)-5-chloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Refernces

• 1、 -. "QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF". . . Retrieved 2017/11/15.
• 2、 -. "PYRAZOLE DERIVATIVES". Page/Page column 38. . Retrieved 2010/11/26.