methyl 3-hydroxy-2-methylpropanoate

Base Information

• Chemical Name: methyl 3-hydroxy-2-methylpropanoate
• CAS No.: 64809-29-6
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.133
• Mol file: 64809-29-6.mol

Synonyms:methyl 3-hydroxy-2-methylpropanoate

Chemical Property of methyl 3-hydroxy-2-methylpropanoate

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-hydroxy-2-methylpropanoate

There total 14 articles about methyl 3-hydroxy-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-hydroxymethylacrylate (15484-46-5) → methyl 3-hydroxy-2-methylpropanoate (64809-29-6,42998-03-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1002/adsc.201000522

Reference yield: 90.0%

(+/-)-methyl 2-methyl-3-(phenylmethoxy)propanoate (59965-24-1) → methyl 3-hydroxy-2-methylpropanoate (64809-29-6,42998-03-8)

Guidance literature:

With hydrogen; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; water; isopropyl alcohol; for 6h;

DOI:10.1080/00397910500466199

Reference yield: 21.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Methyl 2-bromopropionate (5445-17-0) → methyl 3-hydroxy-2-methylpropanoate (64809-29-6,42998-03-8)

Guidance literature:

With zinc copper; In benzene; for 1h; Heating;

DOI:10.1021/jo00133a033

upstream raw materials:

methyl 2-methyl-3-oxopropanoate

formaldehyd

1-methoxypropyne

methyl ester (3-hydroxy) propionic acid

Downstream raw materials:

(+/-)-methyl 2-methyl-3-(phenylmethoxy)propanoate

3-hydroxy-(2S)-methylpropionate

methyl (R)-3-hydroxy-2-methylpropionate

methacrylic acid methyl ester

Refernces

• 1、 Nonaka, Shiori,Sugimoto, Kenji,Ueda, Hirofumi,Tokuyama, Hidetoshi. "Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade". supporting information. p. 380 - 385. Retrieved 2016/02/12.
• 2、 D'Agostino, Carmine,Kotionova, Tatyana,Mitchell, Jonathan,Miedziak, Peter J.,Knight, David W.,Taylor, Stuart H.,Hutchings, Graham J.,Gladden, Lynn F.,Mantle, Mick D.. "Solvent effect and reactivity trend in the aerobic oxidation of 1,3-propanediols over gold supported on titania: Nmr diffusion and relaxation studies". . p. 11725 - 11732. Retrieved 2013/09/12.