Technology Process of (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione
There total 8 articles about (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido-[2,3-d]pyrimidine-4,7(3H,8H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -5 - 20 ℃;
Large scale;
DOI:10.1021/op300198a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide / tetrahydrofuran; water; methanol / 5 h / 20 °C / Large scale
2: trichlorophosphate / acetonitrile / 50 - 74 °C / Large scale
3: sulfuric acid / 20 h / 60 - 80 °C / Large scale
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 63 h / 63 °C / Large scale
5: lithium hexamethyldisilazane / tetrahydrofuran / -5 - 20 °C / Large scale
With
sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; methanol; water; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300198a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trichlorophosphate / acetonitrile / 50 - 74 °C / Large scale
2: sulfuric acid / 20 h / 60 - 80 °C / Large scale
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 63 h / 63 °C / Large scale
4: lithium hexamethyldisilazane / tetrahydrofuran / -5 - 20 °C / Large scale
With
sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300198a