amino acetic acid guacil ester hydrochloride

Base Information

• Chemical Name: amino acetic acid guacil ester hydrochloride
• CAS No.: 75368-99-9
• Molecular Formula: C₉H₁₁NO₃*ClH
• Molecular Weight: 217.652
• Mol file: 75368-99-9.mol

Synonyms:amino acetic acid guacil ester hydrochloride

Chemical Property of amino acetic acid guacil ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of amino acetic acid guacil ester hydrochloride

There total 4 articles about amino acetic acid guacil ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyloxycarbonylamino acetic acid guacil ester (1207070-74-3) → amino acetic acid guacil ester hydrochloride (75368-99-9)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 25 - 30 ℃; for 4h;

DOI:10.1021/op900284w

Reference yield:

2-methoxyphenyl 2-chloroacetate (30287-15-1) → amino acetic acid guacil ester hydrochloride (75368-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone; NaI

2: alcohol; hydrochloric acid

With hydrogenchloride; ethanol; acetone; sodium iodide;

Reference yield:

2-methoxy-phenol (90-05-1) → amino acetic acid guacil ester hydrochloride (75368-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; pyridine

2: acetone; NaI

3: alcohol; hydrochloric acid

With pyridine; hydrogenchloride; diethyl ether; ethanol; acetone; sodium iodide;

upstream raw materials:

2-methoxyphenyl 2-chloroacetate

2-methoxy-phenol

tert-butyloxycarbonylamino acetic acid guacil ester

Downstream raw materials:

amtolmetin guacil

(2-{2-[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]acetylamio}-acetylamino)acetic acid 2-methoxy-phenyl ester

Refernces

• 1、 -. "Guaiacol esters of mercaptopropionic acid derivatives, process for preparing same and therapeutical compositions comprising such esters". . . Retrieved 2008/06/13.