3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride

Base Information

• Chemical Name: 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride
• CAS No.: 133034-08-9
• Molecular Formula: C₂₈H₂₈N₂O₃*ClH
• Molecular Weight: 477.003
• Mol file: 133034-08-9.mol

Synonyms:3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride

Chemical Property of 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride

Chemical Property:

Purity/Quality:

2-Oxodarifenacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Oxodarifenacin is a derivative of Derifenacin hydrobromide (D193400) Used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

Technology Process of 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride

There total 1 articles about 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (134002-25-8,103887-32-7) + 2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone (64089-34-5) → 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride (133034-08-9)

Guidance literature:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide; 2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone; With potassium carbonate; In ethanol; for 16 - 18h;

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; pH=2;

Reference yield:

3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride (133034-08-9) → darifenacin (133099-04-4,133033-93-9)

Guidance literature:

3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride; With hydrogen; acetic acid; 5%-palladium/activated carbon; at 80 - 90 ℃; for 7 - 8h;

With sodium hydroxide; water; pH=10;

upstream raw materials:

2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone

Downstream raw materials:

darifenacin

Refernces