5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide

Base Information

• Chemical Name: 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide
• CAS No.: 1168076-29-6
• Molecular Formula: C₁₅H₁₉NO₃S₂
• Molecular Weight: 325.453
• Mol file: 1168076-29-6.mol

Synonyms:5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide

Chemical Property of 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide

Chemical Property:

Purity/Quality:

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Technology Process of 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide

There total 4 articles about 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-bromo-4-methoxy-benzene (104-92-7) + thiophene-2-sulfonic acid tert-butylamide (100342-30-1) → 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide (1168076-29-6)

Guidance literature:

With potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1002/adsc.202000742

Reference yield: 82.0%

1-bromo-4-methoxy-benzene (104-92-7) + C15H33NO4S2Si3 → 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide (1168076-29-6)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; silver fluoride; In tetrahydrofuran; at 65 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b01972

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + 5-bromothiophene-2-sulphonic acid tert-butylamide (286932-39-6) → 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide (1168076-29-6)

Guidance literature:

With palladium diacetate; sodium carbonate; Tri(p-tolyl)phosphine; In methanol; ethanol; water; at 77 - 83 ℃; for 1.25h; Inert atmosphere; Large scale reaction;

DOI:10.1021/op9000687

upstream raw materials:

4-methoxyphenylboronic acid

5-bromothiophene-2-sulphonic acid tert-butylamide

1-bromo-4-methoxy-benzene

thiophene-2-sulfonic acid tert-butylamide

Downstream raw materials:

4-thiophen-2-yl-phenol

5-(4-hydroxyphenyl)thiophene-2-sulphonic acid tert-butylamide

Refernces

• 1、 Karmel, Caleb,Chen, Zhewei,Hartwig, John F.. "Iridium-Catalyzed Silylation of C-H Bonds in Unactivated Arenes: A Sterically Encumbered Phenanthroline Ligand Accelerates Catalysis". supporting information. p. 7063 - 7072. Retrieved 2019/05/10.